Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ebiom.2016.01.023
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dc.titleIncreased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease - A Population-Based Study
dc.contributor.authorWong, Chee Wai
dc.contributor.authorLamoureux, Ecosse L
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorCheung, Gemmy Chui Ming
dc.contributor.authorTai, E Shyong
dc.contributor.authorWong, Tien Y
dc.contributor.authorSabanayagam, Charumathi
dc.date.accessioned2020-06-05T08:14:17Z
dc.date.available2020-06-05T08:14:17Z
dc.date.issued2016-03-01
dc.identifier.citationWong, Chee Wai, Lamoureux, Ecosse L, Cheng, Ching-Yu, Cheung, Gemmy Chui Ming, Tai, E Shyong, Wong, Tien Y, Sabanayagam, Charumathi (2016-03-01). Increased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease - A Population-Based Study. EBIOMEDICINE 5 : 193-197. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ebiom.2016.01.023
dc.identifier.issn2352-3964
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169459
dc.description.abstract© 2016 The Authors. Background: Chronic kidney disease (CKD) has been shown to be associated with diabetic retinopathy (DR) and age-related macular degeneration (AMD), leading causes of blindness in elderly adults in previous studies. However, the association of CKD with visual impairment (VI) is not clear. We aimed to examine the association of CKD with VI and other age-related ocular diseases in a population-based sample of Asian adults. Methods: We analyzed data from 10,033 adults aged 40-80 years who participated in the Singapore Epidemiology of Eye Diseases (SEED, 2004-11) Study. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m 2 from serum creatinine. VI was defined as best-corrected visual acuity <20/40 in the better eye. Cataract, retinopathy, DR, glaucoma and AMD were assessed using standardized ocular examination, retinal photography and visual field assessments. The associations of CKD with VI and ocular conditions were examined using logistic regression models adjusted for age, sex, race, smoking, alcohol intake, education status, body mass index, systolic blood pressure, diabetes mellitus, cholesterol levels and cardiovascular disease. Findings: The prevalence of VI and ocular disease were significantly higher in participants with CKD (36.1% and 84.7%) than in those without (12.9% and 54.3%, both p < 0.001). In multivariable models, CKD was significantly associated with VI (odds ratio [95% confidence interval] = 1.34 [1.14-1.58]), any ocular disease (1.28 [1.03-1.61]), cataract (1.24 [1.01-1.52]), any retinopathy (1.77 [1.45-2.15]), and DR (1.94 [1.47-2.54]). Interpretation: The burden of VI and eye diseases is high among persons with CKD. Our findings suggest that it may be useful to screen for ocular disease and VI in persons with CKD.
dc.language.isoen
dc.publisherELSEVIER
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMedicine, General & Internal
dc.subjectMedicine, Research & Experimental
dc.subjectGeneral & Internal Medicine
dc.subjectResearch & Experimental Medicine
dc.subjectChronic kidney disease
dc.subjectVisual impairment
dc.subjectOcular disease
dc.subjectCataract
dc.subjectRetinopathy
dc.subjectVISUAL IMPAIRMENT
dc.subjectMACULAR DEGENERATION
dc.subjectRISK-FACTORS
dc.subjectPREVALENCE
dc.subjectMORTALITY
dc.subjectABNORMALITIES
dc.subjectALBUMINURIA
dc.subjectGLYCATION
dc.subjectCATARACT
dc.subjectIMPACT
dc.typeArticle
dc.date.updated2020-06-03T14:08:39Z
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.ebiom.2016.01.023
dc.description.sourcetitleEBIOMEDICINE
dc.description.volume5
dc.description.page193-197
dc.published.statePublished
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