Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/16904
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dc.titleActivities of the cytokine receptor CD137 in multiple myeloma
dc.contributor.authorKOH LIANG KAI
dc.date.accessioned2010-05-13T18:03:22Z
dc.date.available2010-05-13T18:03:22Z
dc.date.issued2009-08-11
dc.identifier.citationKOH LIANG KAI (2009-08-11). Activities of the cytokine receptor CD137 in multiple myeloma. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/16904
dc.description.abstractMultiple myeloma is an incurable hematological malignancy derived from B cells, and characterized by bone destruction and multiple organ dysfunctions. CD137 and its ligand are members of the Tumor Necrosis Factor (TNF) Receptor and TNF superfamilies, respectively. CD137 enhances proliferation and survival in healthy B cells. Since CD137 can be expressed as a neoantigen by certain B cell lymphomas, we hypothesized that CD137 may act as a growth factor for B cell lymphomas. Surprisingly, we found that CD137 has the opposite effects in multiple myeloma (MM) cells, where it inhibits proliferation and induces cell death by apoptosis. In contrast, CD137 does not significantly affect or enhance proliferation or survival in non-MM B cell lymphoma lines. Further secretion of IL-6 and IL-8 is also enhanced in MM but not in non-MM cell lines in response to CD137. A selective elimination of malignant B cells in MM patients by CD137 could help to slow down disease progression and reduce the doses (and hence side effects) in conjunction with conventional treatment regimes.
dc.language.isoen
dc.subjectmyeloma, cd137, receptor, cytokine, apoptosis, TNF
dc.typeThesis
dc.contributor.departmentPHYSIOLOGY
dc.contributor.supervisorSCHWARZ, HERBERT
dc.description.degreeMaster's
dc.description.degreeconferredMASTER OF SCIENCE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Master's Theses (Open)

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