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https://doi.org/10.1016/j.ydbio.2019.07.009
Title: | Zebrafish and medaka as models for biomedical research of bone diseases | Authors: | Lleras-Forero, L Winkler, C Schulte-Merker, S |
Issue Date: | 15-Jan-2020 | Publisher: | Elsevier BV | Citation: | Lleras-Forero, L, Winkler, C, Schulte-Merker, S (2020-01-15). Zebrafish and medaka as models for biomedical research of bone diseases. Developmental Biology 457 (2) : 191-205. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ydbio.2019.07.009 | Abstract: | © 2019 Elsevier Inc. The identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available. | Source Title: | Developmental Biology | URI: | https://scholarbank.nus.edu.sg/handle/10635/168947 | ISSN: | 00121606 1095564X |
DOI: | 10.1016/j.ydbio.2019.07.009 |
Appears in Collections: | Elements Staff Publications |
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Lleras-Forrero et al., Dev Biol 2019 for upload.docx | Accepted version | 1 MB | Microsoft Word XML | OPEN | Post-print | View/Download |
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