Please use this identifier to cite or link to this item: https://doi.org/10.1039/c7nr06007f
Title: Graphene oxide inhibits malaria parasite invasion and delays parasitic growth in vitro
Authors: Kenry 
Lim, Ying Bena
Nai, Mui Hoon 
Cao, Jianshu
Loh, Kian Ping 
Lim, Chwee Teck 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
PLASMODIUM-FALCIPARUM MALARIA
HUMAN SERUM-ALBUMIN
LATERAL DIMENSION
CELLS
SIZE
CHALLENGES
CHEMISTRY
DELIVERY
Issue Date: 2017
Publisher: ROYAL SOC CHEMISTRY
Citation: Kenry, Lim, Ying Bena, Nai, Mui Hoon, Cao, Jianshu, Loh, Kian Ping, Lim, Chwee Teck (2017). Graphene oxide inhibits malaria parasite invasion and delays parasitic growth in vitro. NANOSCALE 9 (37) : 14065-14073. ScholarBank@NUS Repository. https://doi.org/10.1039/c7nr06007f
Abstract: © The Royal Society of Chemistry 2017. The interactions between graphene oxide (GO) and various biological entities have been actively investigated in recent years, resulting in numerous potential bioapplications of these nanomaterials. Despite this, the biological interactions between GO and disease-causing protozoan parasites have not been well elucidated and remain relatively unexplored. Here, we investigate the in vitro interactions between GO nanosheets and a particular species of malaria parasites, Plasmodium falciparum (P. falciparum). We hypothesize that GO nanosheets may exhibit antimalarial characteristic via action mechanisms of physical obstruction of P. falciparum parasites as well as nutrient depletion. To ascertain this, we characterize the physical interactions between GO nanosheets, red blood cells (RBCs), and malarial parasites as well as the adsorption of several biomolecules necessary for parasitic survival and growth on GO nanosheets. Subsequent to establishing the origin of this antimalarial behavior of GO nanosheets, their efficiency in inhibiting parasite invasion is evaluated. We observe that GO nanosheets at various tested concentrations significantly inhibit the invasion of malaria parasites into RBCs. Furthermore, GO nanosheets delay parasite progression from the ring to the trophozoite stage. Overall, this study may further shed light on the graphene-parasite interactions and potentially facilitate the development of nanomaterial-based strategies for combating malaria.
Source Title: NANOSCALE
URI: https://scholarbank.nus.edu.sg/handle/10635/168855
ISSN: 20403364
20403372
DOI: 10.1039/c7nr06007f
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