Please use this identifier to cite or link to this item:
https://doi.org/10.1002/adfm.201907077
Title: | Nanostructural Control Enables Optimized Photoacoustic-Fluorescence-Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor | Authors: | Duan, Yukun Hu, Dehong Guo, Bing Shi, Qi Wu, Min Xu, Shidang Kenry Liu, Xin Jiang, Jianwen Sheng, Zonghai Zheng, Hairong Liu, Bin |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics brain tumor theranostics fluorescence imaging magnetic resonance imaging photoacoustic imaging photothermal therapy IRON-OXIDE NANOPARTICLES PARTICLE MESH EWALD ORGANIC NANOPARTICLES POLYMERIC MICELLES TARGETED DELIVERY PROGRESS GLIOBLASTOMA |
Issue Date: | 4-Nov-2019 | Publisher: | WILEY-V C H VERLAG GMBH | Citation: | Duan, Yukun, Hu, Dehong, Guo, Bing, Shi, Qi, Wu, Min, Xu, Shidang, Kenry, Liu, Xin, Jiang, Jianwen, Sheng, Zonghai, Zheng, Hairong, Liu, Bin (2019-11-04). Nanostructural Control Enables Optimized Photoacoustic-Fluorescence-Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor. ADVANCED FUNCTIONAL MATERIALS 30 (1). ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201907077 | Abstract: | © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The performance of current multimodal imaging contrast agents is often constrained by the tunability of nanomaterial structural design. Herein, the influence of nanostructure on the overall imaging performance of a composite nanomaterial for multimodal imaging of brain tumors is studied. Newly designed near-infrared molecules (TC1) are encapsulated into nanocomposites with ultrasmall iron oxide nanoparticles (UIONPs), forming stable nanoagents for multimodal imaging and photothermal therapy (PTT). Through a modified nanoprecipitation method, the synthesis of nanocomposites denoted as HALF is realized, in which UIONPs are restricted to half of the nanosphere. Such a unique nanostructure that physically separates TC1 and UIONPs is found with capabilities of mitigating fluorescence quenching, preserving the good performance of photoacoustic imaging, and enhancing the magnetic resonance imaging signals. Decorated with a peptide ligand cRGD for better brain tumor targeting, HALF-cRGD is evaluated both in vitro and in vivo as imaging contrast agents and photothermal therapeutic agents. The good imaging performance and PTT effect of HALF-cRGD in mice models indicate that the rational design and control of nanostructures could optimize multimodal imaging performance using the same components. | Source Title: | ADVANCED FUNCTIONAL MATERIALS | URI: | https://scholarbank.nus.edu.sg/handle/10635/168831 | ISSN: | 1616301X 16163028 |
DOI: | 10.1002/adfm.201907077 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
adfm.201907077_R1.pdf | Accepted version | 2.41 MB | Adobe PDF | OPEN | Post-print | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.