Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201800652
Title: Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal
Authors: Duan, Yukun 
Xu, Yu
Mao, Duo 
Liew, Weng Heng
Guo, Bing 
Wang, Shaowei 
Cai, Xiaolei 
Thakor, Nitish 
Yao, Kui
Zhang, Chong-Jing
Liu, Bin
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
conjugated polymer
finite element analysis
iron oxide nanoparticle
magnetic resonance imaging
photoacoustic imaging
SEMICONDUCTING POLYMER NANOPARTICLES
PHOTOTHERMAL THERAPY
OXIDE NANOPARTICLES
HEAT-CAPACITY
RELAXIVITY
LASER
MRI
Issue Date: 18-Oct-2018
Publisher: WILEY-V C H VERLAG GMBH
Citation: Duan, Yukun, Xu, Yu, Mao, Duo, Liew, Weng Heng, Guo, Bing, Wang, Shaowei, Cai, Xiaolei, Thakor, Nitish, Yao, Kui, Zhang, Chong-Jing, Liu, Bin (2018-10-18). Photoacoustic and Magnetic Resonance Imaging Bimodal Contrast Agent Displaying Amplified Photoacoustic Signal. SMALL 14 (42). ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201800652
Abstract: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Progress in photoacoustic (PA) and magnetic resonance imaging (MRI) bimodal contrast agents has been achieved mainly by utilizing the imaging capability of single or multiple components and consequently realizing the desired application for both imaging modalities. However, the mechanism of the mutual influence between components within a single nanoformulation, which is the key to developing high-performance multimodal contrast agents, has yet to be fully understood. Herein, by integrating conjugated polymers (CPs) with iron oxide (IO) nanoparticles using an amphiphilic polymer, a bimodal contrast agent named CP-IO is developed, displaying 45% amplified PA signal intensity as compared to bare CP nanoparticle, while the performance of MRI is not affected. Further experimental and theoretical simulation results reveal that the addition of IO nanoparticles in CP-IO nanocomposites contributes to this PA signal amplification through a synergistic effect of additional heat generation and faster heat dissipation. Besides, the feasibility of CP-IO nanocomposites acting as PA-MRI bimodal contrast agents is validated through in vivo tumor imaging using mice models. From this study, it is demonstrated that a delicately designed structural arrangement of various components in a contrast agent could potentially lead to a superior performance in the imaging capability.
Source Title: SMALL
URI: https://scholarbank.nus.edu.sg/handle/10635/168829
ISSN: 16136810
16136829
DOI: 10.1002/smll.201800652
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