Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.celrep.2016.04.027
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dc.titleHippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.
dc.contributor.authorSingh A
dc.contributor.authorRamesh S
dc.contributor.authorCibi DM
dc.contributor.authorYun LS
dc.contributor.authorLi J
dc.contributor.authorLi L
dc.contributor.authorManderfield LJ
dc.contributor.authorOlson EN
dc.contributor.authorEpstein JA
dc.contributor.authorSingh MK
dc.date.accessioned2020-05-21T07:46:46Z
dc.date.available2020-05-21T07:46:46Z
dc.date.issued2016-05-21
dc.identifier.citationSingh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK (2016-05-21). Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.. Cell Reports 15 (7) : 1384-1393. ScholarBank@NUS Repository. https://doi.org/10.1016/j.celrep.2016.04.027
dc.identifier.issn22111247
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/168380
dc.publisherElsevier
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.celrep.2016.04.027
dc.description.sourcetitleCell Reports
dc.description.volume15
dc.description.issue7
dc.description.page1384-1393
dc.published.statePublished
dc.grant.fundingagencyNRF-NRFF2016-01
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2016. Singh et al. Cell Reports.pdfFormation of the coronary vasculature is a complex and precisely coordinated morphogenetic process that begins with the formation of epicardium. The epicardium gives rise to many components of the coronary vasculature, including fibroblasts, smooth muscle cells, and endothelium. Hippo signaling components have been implicated in cardiac development and regeneration. However, a role of Hippo signaling in the epicardium has not been explored. Employing a combination of genetic and pharmacological approaches, we demonstrate that inhibition of Hippo signaling mediators Yap and Taz leads to impaired epicardial epithelial-to-mesenchymal transition (EMT) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells. We provide evidence that Yap and Taz control epicardial cell behavior, in part by regulating Tbx18 and Wt1 expression. Our findings show a role for Hippo signaling in epicardial cell proliferation, EMT, and cell fate specification during cardiac organogenesis.9.44 MBAdobe PDF

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