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Title: Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.
Authors: Singh A 
Ramesh S 
Cibi DM 
Yun LS
Li J
Li L
Manderfield LJ
Olson EN
Epstein JA
Singh MK 
Issue Date: 21-May-2016
Publisher: Elsevier
Citation: Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK (2016-05-21). Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.. Cell Reports 15 (7) : 1384-1393. ScholarBank@NUS Repository.
Source Title: Cell Reports
ISSN: 22111247
DOI: 10.1016/j.celrep.2016.04.027
Appears in Collections:Staff Publications

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2016. Singh et al. Cell Reports.pdfFormation of the coronary vasculature is a complex and precisely coordinated morphogenetic process that begins with the formation of epicardium. The epicardium gives rise to many components of the coronary vasculature, including fibroblasts, smooth muscle cells, and endothelium. Hippo signaling components have been implicated in cardiac development and regeneration. However, a role of Hippo signaling in the epicardium has not been explored. Employing a combination of genetic and pharmacological approaches, we demonstrate that inhibition of Hippo signaling mediators Yap and Taz leads to impaired epicardial epithelial-to-mesenchymal transition (EMT) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells. We provide evidence that Yap and Taz control epicardial cell behavior, in part by regulating Tbx18 and Wt1 expression. Our findings show a role for Hippo signaling in epicardial cell proliferation, EMT, and cell fate specification during cardiac organogenesis.9.44 MBAdobe PDF




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