Please use this identifier to cite or link to this item: https://doi.org/10.1111/dme.13358
Title: Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany
Authors: Ong, YH
Koh, WCA
Ng, ML
Tam, ZY 
Lim, SC 
Boehm, BO
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
BROAD CLINICAL PHENOTYPE
AUTOANTIBODY ASSAYS
INSULIN REQUIREMENT
LADA CHINA
AUTOIMMUNE
TYPE-1
GAD
PREVALENCE
PREDICTION
REGION
Issue Date: 1-Aug-2017
Publisher: WILEY
Citation: Ong, YH, Koh, WCA, Ng, ML, Tam, ZY, Lim, SC, Boehm, BO (2017-08-01). Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany. DIABETIC MEDICINE 34 (8) : 1145-1153. ScholarBank@NUS Repository. https://doi.org/10.1111/dme.13358
Abstract: © 2017 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK Aim: To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population. Methods: For this cross-sectional study we recruited people with adult-onset diabetes (age of diagnosis 20–60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols. Results: The prevalence of glutamic acid decarboxylase antibody positivity was 13.9% (95% CI 12.1–16.0; P<0.001) in the white European cohort compared with 6.8% (95% CI 5.5–8.4; P<0.001) in the Asian cohort. Glutamic acid decarboxylase antibody positivity was 11.4% (95% CI 7.7–16.6) in Indian, 6.0% (95% CI 3.6–9.9) in Malay and 5.8% (95% CI 4.3–7.7; P<0.001) in Chinese participants. In the white European participants, the prevalence of islet antigen 2 antibody positivity was 7.8% (95% CI 6.4–9.4) compared with 14.8% (95% CI 12.8–17.0; P<0.001) in the Asian cohort as a whole, and among the three ethnicities in the Asian cohort it was 12.4% (95% CI 8.6–17.7) in Indian, 16.8% (95% CI 12.6–22.2) in Malay and 15.7% (95% CI 13.2–18.6) in Chinese participants. Double antibody positivity was seen in 5.7% (95% CI 4.5–7.1) of white European participants compared with 1.6% (95% CI 1.0–2.5; P<0.01) of Asian participants. In the white European cohort, those who were glutamic acid decarboxylase autoantibody-positive had a lower BMI than those who were autoantibody-negative, but this trend was absent in the Asian cohort. Conclusions: A marked prevalence of islet cell autoimmunity was observed in people with adult-onset diabetes. While glutamic acid decarboxylase antibodies were more frequent in the European cohort, islet antigen 2 antibody positivity was highest in the three ethnic groups in Singapore, suggesting ethnic-specific differences in antibody profiles.
Source Title: DIABETIC MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/168153
ISSN: 07423071
14645491
DOI: 10.1111/dme.13358
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