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Title: Epithelial-Mesenchymal transition in Breast Cancer Progression
Keywords: EMT, Epithelial-mesenchymal transition, ductal carcinoma in situ, invasive ductal carcinoma, SPARC, N-cadherin
Issue Date: 17-Sep-2009
Citation: KELLY LIM SWEE YING (2009-09-17). Epithelial-Mesenchymal transition in Breast Cancer Progression. ScholarBank@NUS Repository.
Abstract: Epithelial-mesenchymal transition (EMT), in which epithelial cells lose their epithelial characteristics and gain mesenchymal features, is a process crucial in cancer progression. EMT induces a phenotypic, molecular and behavioural change in carcinoma cells, permitting them to invade and metastasise. In our study on breast cancer tissue using microarray analysis validated by qRT-PCR and IHC, we investigated genes that are differentially expressed in breast cancer progression. Overall, 65 EMT-related genes were identified; 36 at the normal to ductal carcinoma in situ transition and 29 at the ductal carcinoma in situ to invasive ductal carcinoma transition. This suggests that EMT is a multi-step process, as opposed to an all-or-nothing event. Changes in EMT-related gene and protein expression can and do occur as early as the normal to DCIS transition, but further accumulate as the cancer progresses from DCIS to IDC, eventually culminating in phenotypic changes sufficient for cellular invasion and metastasis.
Appears in Collections:Master's Theses (Open)

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