Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2018.00155
DC FieldValue
dc.titleRewriting the metabolic blueprint: advances in pathway diversification in microorganisms
dc.contributor.authorGAZI SAKIR HOSSAIN
dc.contributor.authorSARAVANAN PRABHU NADARAJAN
dc.contributor.authorZHANG LEI
dc.contributor.authorNG TEE KHEANG
dc.contributor.authorFOO JEE LOON
dc.contributor.authorLING HUA
dc.contributor.authorCHOI WON JAE
dc.contributor.authorChang,Matthew Wook
dc.date.accessioned2020-05-11T01:57:25Z
dc.date.available2020-05-11T01:57:25Z
dc.date.issued2018-02-12
dc.identifier.citationGAZI SAKIR HOSSAIN, SARAVANAN PRABHU NADARAJAN, ZHANG LEI, NG TEE KHEANG, FOO JEE LOON, LING HUA, CHOI WON JAE, Chang,Matthew Wook (2018-02-12). Rewriting the metabolic blueprint: advances in pathway diversification in microorganisms. Frontiers in Microbiology 9 (FEB) : 155. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2018.00155
dc.identifier.issn1664-302X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/167911
dc.description.abstractLiving organisms have evolved over millions of years to fine tune their metabolism to create efficient pathways for producing metabolites necessary for their survival. Advancement in the field of synthetic biology has enabled the exploitation of these metabolic pathways for the production of desired compounds by creating microbial cell factories through metabolic engineering, thus providing sustainable routes to obtain value-added chemicals. Following the past success in metabolic engineering, there is increasing interest in diversifying natural metabolic pathways to construct non-natural biosynthesis routes, thereby creating possibilities for producing novel valuable compounds that are non-natural or without elucidated biosynthesis pathways. Thus, the range of chemicals that can be produced by biological systems can be expanded to meet the demands of industries for compounds such as plastic precursors and new antibiotics, most of which can only be obtained through chemical synthesis currently. Herein, we review and discuss novel strategies that have been developed to rewrite natural metabolic blueprints in a bid to broaden the chemical repertoire achievable in microorganisms. This review aims to provide insights on recent approaches taken to open new avenues for achieving biochemical production that are beyond currently available inventions.
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2018.00155/full
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectMetabolic engineering
dc.subjectSynthetic biology
dc.subjectPathway engineering
dc.subjectProtein engineering
dc.subjectBiochemical production
dc.typeReview
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.3389/fmicb.2018.00155
dc.description.sourcetitleFrontiers in Microbiology
dc.description.volume9
dc.description.issueFEB
dc.description.page155
dc.published.statePublished
dc.grant.idDPRT/943/09/14
dc.grant.idMOE/2014/T2/2/128
dc.grant.idN0000677,SBP-P2
dc.grant.fundingagencySynthetic Biology Initiative of the National University of Singapore
dc.grant.fundingagencyMinistry of Education, Singapore
dc.grant.fundingagencyMinistry of Knowledge Economy
dc.description.redepositcompleted
dc.description.redepositcompleted
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Rewriting the Metabolic Blueprint Advances in Pathway Diversification in Microorganisms.pdfPublished version1.98 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

7
checked on Mar 23, 2023

WEB OF SCIENCETM
Citations

5
checked on Oct 5, 2021

Page view(s)

239
checked on Mar 16, 2023

Download(s)

4
checked on Mar 16, 2023

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.