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Title: Crystal Structure Determination of KREMEN1, DICKKOPF1 and MeCP2
Keywords: Wnt,Kremen,Dickkopf,Methyl,Cpg,crystal
Issue Date: 6-Jan-2009
Citation: VINDHYA BANGALORE NARAYANA REDDY (2009-01-06). Crystal Structure Determination of KREMEN1, DICKKOPF1 and MeCP2. ScholarBank@NUS Repository.
Abstract: The canonical Wnt/beta catenin signaling pathway has been implicated in the development of skin appendages like hair follicle, teeth and mammary glands. Slight perturbations in this pathway lead to severe mammalian developmental defects in bone and eye formation, degenerative diseases and cancer. Kremen1 (Krm1), a transmembrane receptor, in association with the Dkk family protein Dickkopf1 (Dkk1), represses the pathway thereby regulating gastrulation events in Xenopus laevis. Therefore, we sought to investigate the mechanism of action of these antagonists by studying the crystal structure of the complex of Krm1 with Dkk1. DNA methylation has an essential regulatory function of repressing non-transcribed genes stably in differentiated adult somatic cells. MeCP2, a methyl CpG-binding protein, is one abundant mammalian protein which contributes to methylation dependent gene silencing. The determination of crystal structure of MeCP2 could aid us in understanding its protein transcription repression mechanism. Moreover, it could provide fundamental insights into the epigenetic modifications that affect mammalian development and normal cellular homeostasis.
Appears in Collections:Master's Theses (Open)

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