Please use this identifier to cite or link to this item:
Title: Effects and mechanisms of a concentrated goyasaponin fraction in 3T3-L1 cell line
Authors: LI LU
Keywords: Momordica Charantia, goyasaponins, 3T3-L1, adiponectin, PPARr, TZDs
Issue Date: 4-Mar-2009
Citation: LI LU (2009-03-04). Effects and mechanisms of a concentrated goyasaponin fraction in 3T3-L1 cell line. ScholarBank@NUS Repository.
Abstract: Momordica charantia is widely used as a traditional food for the treatment of type 2 diabetes. Although hypoglycemic effect of goyasaponin fraction has been proven on rats, much less is known about its in vitro mechanisms, especially on adipose tissue, a target tissue for antidiabetic drugs. A variety of goyasaponin compounds were identified in both Fruit and Seed CGF on the basis of molecular fragment match to reported molecular weights. Our findings suggest Fruit CGF might obtain an anti-obesity effect but it does not show a potential as a PPARr agonist on this in vitro model as Fruit CGF neither enhanced adipogenesis nor promoted adiponectin secretion from differentiated adipocytes. Therefore, unlike TZDs treatment, hypoglycemic effect of Fruit CGF might be achieved via different pathways. Moreover, our results also suggest that Seed CGF displayed similar effects when compared to the edible portion and it may have the potential for future nutraceutical development.
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
1. Title Page.pdf8.84 kBAdobe PDF


2. Acknowledgements Summary Table of Contents.pdf81.64 kBAdobe PDF


3. Main body of thesis.pdf1.29 MBAdobe PDF



Page view(s)

checked on Apr 20, 2019


checked on Apr 20, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.