Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/16708
DC FieldValue
dc.titleCo-operation between humoral and cellular immunity in pulmonary lung inflammation
dc.contributor.authorDEEPA D/O MOHANAN
dc.date.accessioned2010-04-08T11:08:09Z
dc.date.available2010-04-08T11:08:09Z
dc.date.issued2009-01-22
dc.identifier.citationDEEPA D/O MOHANAN (2009-01-22). Co-operation between humoral and cellular immunity in pulmonary lung inflammation. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/16708
dc.description.abstractAsthma is a respiratory disease, characterized by elevated serum immunoglobulin E (IgE) levels, chronic eosinophilic airway inflammation, and airway hyperresponsiveness (AHR). In vivo studies have shown that interleukin4 (IL-4), IL-5, and IL-13 are involved in allergic asthma development. The role of T lymphocytes in asthma has been extensively studied but the role of IgE in asthma is not well understood. It was recently shown that IgE is able to induce activation of T cells in the presence of antigen in vivo. Therefore we hypothesize that the role of IgE is in aiding the response elicted by CD4 Th2 cells during asthma. Using an IgE passive sensitization model together with the adoptive transfer model, we have shown that there was no recruitment of eosinophils in the airways or antigen specific T cells in the lungs when mice were given both antigen-specific IgE and polarized Th2 cells.
dc.language.isoen
dc.subjectAsthma, murine, IgE, T-cells, adoptive transfer
dc.typeThesis
dc.contributor.departmentMICROBIOLOGY
dc.contributor.supervisorKEMENY, DAVID MICHAEL
dc.description.degreeMaster's
dc.description.degreeconferredMASTER OF SCIENCE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Master's Theses (Open)

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
MSC Thesis.pdf1.09 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

209
checked on May 23, 2019

Download(s)

170
checked on May 23, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.