Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0080123
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dc.titleExercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner
dc.contributor.authorGoh J.
dc.contributor.authorTsai J.
dc.contributor.authorBammler T.K.
dc.contributor.authorFarin F.M.
dc.contributor.authorEndicott E.
dc.contributor.authorLadiges W.C.
dc.date.accessioned2020-04-08T04:46:39Z
dc.date.available2020-04-08T04:46:39Z
dc.date.issued2013
dc.identifier.citationGoh J., Tsai J., Bammler T.K., Farin F.M., Endicott E., Ladiges W.C. (2013). Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner. PLoS ONE 8 (11) : e80123. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0080123
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/166573
dc.description.abstractEpidemiological research suggests that regular physical activity confers beneficial effects that mediate an anti-tumor response and may reduce cancer recurrence. It is unclear what amount of physical activity is necessary to exert such a protective effect and what mechanisms are involved. We investigated the effects of voluntary wheel running on tumor progression and cytokine gene expression in the transgenic polyoma middle T oncoprotein (PyMT) mouse model of invasive breast cancer. Runners showed significantly reduced tumor sizes compared with non-runners after 3 weeks of running (p?0.01), and the greater the running distance the smaller the tumor size (Pearson's r = 20.61, p?0.04, R2 = 0.38). Mice running greater than 150 km per week had a significantly attenuated tumor size compared with non-runners (p?0.05). Adipose tissue mass was inversely correlated with tumor size in runners (Pearson's r = 20.77, p = 0.014) but not non-runners. Gene expression of CCL22, a cytokine associated with recruitment of immunosuppressive T regulatory cells, was decreased in tumors of runners compared to non-runners (p?0.005). No differences in tumor burden or metastatic burden were observed between runners and non-runners after ten weeks of running when the study was completed. We conclude that voluntary wheel running in PyMT mice correlates with an attenuation in tumor progression early during the course of invasive breast cancer. This effect is absent in the later stages of overwhelming tumor burden even though cytokine signaling for immunosuppressive regulatory T cells was down regulated. These observations suggest that the initiation of moderate exercise training for adjunctive therapeutic benefit early in the course of invasive breast cancer should be considered for further investigation. © 2013 Goh et al.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectBody Composition
dc.subjectBreast Neoplasms
dc.subjectCytokines
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectGene Expression
dc.subjectMale
dc.subjectMammary Neoplasms, Animal
dc.subjectMice
dc.subjectMice, Transgenic
dc.subjectOrgan Size
dc.subjectPhysical Conditioning, Animal
dc.subjectSpleen
dc.subjectTumor Burden
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.1371/journal.pone.0080123
dc.description.sourcetitlePLoS ONE
dc.description.volume8
dc.description.issue11
dc.description.pagee80123
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