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https://scholarbank.nus.edu.sg/handle/10635/166546
DC Field | Value | |
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dc.title | IMMUNOMODULATORY ROLE OF HEPATITIS DELTA VIRUS (HDV) DURING HBV INFECTION | |
dc.contributor.author | THAM YAN LIN | |
dc.date.accessioned | 2020-04-07T18:00:28Z | |
dc.date.available | 2020-04-07T18:00:28Z | |
dc.date.issued | 2019-08-21 | |
dc.identifier.citation | THAM YAN LIN (2019-08-21). IMMUNOMODULATORY ROLE OF HEPATITIS DELTA VIRUS (HDV) DURING HBV INFECTION. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/166546 | |
dc.description.abstract | Hepatitis Delta virus (HDV) requires hepatitis B virus (HBV) to complete its infection cycle and causes a severe hepatitis with limited therapeutic options. To determine the prospect of T cell therapy in HBV/HDV co-infection, we first studied the HDV impact on viral antigen processing and presentation. Utilizing in vitro models of HBV/HDV co-infection, we demonstrated that HDV boosts HBV epitope presentation, both in HBV/HDV co-infected and neighboring mono-HBV infected cells through up-regulation of antigen processing pathway mediated by IFN-beta/lambda. This up-regulation was confirmed in liver biopsies of HBV/HDV patients. We then demonstrated in vitro and in HBV/HDV preclinical mouse model that HDV increases the antiviral efficacy of HBV-specific T cell receptors engineered T cells. Thus, by unveiling the effect of HDV on HBV antigen presentation, we provide a framework to better understand HBV/HDV immune pathology, and we advocate the use of engineered HBV-specific T cells for the treatment of HBV/HDV co-infection. | |
dc.language.iso | en | |
dc.subject | Viral hepatitis, chronic liver disease, immunotherapy, CAR-T cell therapy | |
dc.type | Thesis | |
dc.contributor.department | INTEGRATIVE SCIENCES & ENGINEERING PROG | |
dc.contributor.supervisor | Antonio Bertoletti | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY (NUSGS) | |
Appears in Collections: | Ph.D Theses (Open) |
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