Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0054406
Title: Toll-Like Receptor Ligands Induce Expression of the Costimulatory Molecule CD155 on Antigen-Presenting Cells
Authors: Kamran N.
Takai Y.
Miyoshi J.
Biswas S.K. 
Wong J.S.B. 
Gasser S. 
Keywords: CpG oligodeoxynucleotide
decay accelerating factor
immunoglobulin
immunoglobulin enhancer binding protein
immunoglobulin G2a
immunoglobulin g2c
interferon regulatory factor 3
interferon regulatory factor 7
interleukin 4
myeloid differentiation factor 88
ovalbumin
toll like receptor
toll like receptor 3
toll like receptor adaptor molecule 1
transcription factor GATA 3
unclassified drug
animal cell
animal experiment
antigen expression
antigen presenting cell
article
B lymphocyte
CD4+ T lymphocyte
controlled study
cytokine release
dendritic cell
human
human cell
immunization
macrophage
mouse
nonhuman
protein expression
spleen cell
upregulation
Adaptor Proteins, Vesicular Transport
Animals
Antigens, Differentiation, T-Lymphocyte
CD4-Positive T-Lymphocytes
Cell Differentiation
DNA Damage
GATA3 Transcription Factor
Gene Expression Regulation
Immunity, Humoral
Ligands
Mice
Myeloid Differentiation Factor 88
Receptors, Virus
Spleen
Th2 Cells
Toll-Like Receptor 3
Viral Vaccines
Mus
Issue Date: 2013
Publisher: Public Library of Science
Citation: Kamran N., Takai Y., Miyoshi J., Biswas S.K., Wong J.S.B., Gasser S. (2013). Toll-Like Receptor Ligands Induce Expression of the Costimulatory Molecule CD155 on Antigen-Presenting Cells. PLoS ONE 8 (1) : e54406. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0054406
Abstract: Genotoxic stress and RAS induce the expression of CD155, a ligand for the immune receptors DNAM-1, CD96 and TIGIT. Here we show that antigen-presenting cells upregulate CD155 expression in response to Toll-like receptor activation. Induction of CD155 by Toll-like receptors depended on MYD88, TRIF and NF-?B. In addition, IRF3, but not IRF7, modulated CD155 upregulation in response to TLR3 signals. Immunization of CD155-deficient mice with OVA and the TLR9 agonist CpG resulted in increased OVA-specific IgG2a/c titers when compared to wild type mice. Splenocytes of immunized CD155-deficient mice secreted lower levels of IL-4 and fewer IL-4 and GATA-3 expressing CD4+ T cells were present in the spleen of Cd155-/- mice. Our data suggest that CD155 regulates Th2 differentiation. Targeting of CD155 in immunization protocols using peptides may represent a promising new approach to boost protective humoral immunity in viral vaccines. © 2013 Kamran et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/166202
ISSN: 19326203
DOI: 10.1371/journal.pone.0054406
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