Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0056702
Title: Elite Model for the Generation of Induced Pluripotent Cancer Cells (iPCs)
Authors: Lai J. 
Kong C.M. 
Mahalingam D. 
Xie X. 
Wang X. 
Keywords: cyclin dependent kinase inhibitor 2A
cyclin dependent kinase inhibitor 2B
DNA
protein p53
RNA
animal cell
animal experiment
animal model
article
cancer cell
CDKN2A gene
CDKN2B gene
cell heterogeneity
controlled study
elite model
fetus
gene deletion
gene expression
gene mutation
human
human cell
induced pluripotent cancer cell
microarray analysis
model
mouse
nonhuman
nuclear reprogramming
parsimony analysis
pluripotent stem cell
reverse transcription polymerase chain reaction
TP53 gene
Western blotting
Animals
Blotting, Western
Cell Line
Cell Line, Tumor
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Gene Expression Regulation, Neoplastic
HeLa Cells
Humans
Induced Pluripotent Stem Cells
Mice
Mice, Nude
Mice, SCID
Models, Genetic
Molecular Sequence Data
Neoplasms, Experimental
Neoplastic Stem Cells
Nuclear Reprogramming
Pluripotent Stem Cells
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Transplantation, Heterologous
Tumor Suppressor Protein p53
Issue Date: 2013
Publisher: Public Library of Science
Citation: Lai J., Kong C.M., Mahalingam D., Xie X., Wang X. (2013). Elite Model for the Generation of Induced Pluripotent Cancer Cells (iPCs). PLoS ONE 8 (2) : e56702. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0056702
Abstract: The inefficiency of generating induced pluripotent somatic cells (iPS) engendered two contending models, namely the Stochastic model and Elite model. Although the former is more favorable to explain the inherent inefficiencies, it may be fallible to extrapolate the same working model to reprogramming of cancer cells. Indeed, tumor cells are known to be inherently heterogeneous with respect to distinctive characteristics thus providing a suitable platform to test whether the reprogramming process of cancer cells is biased. Here, we report our observations that all randomly picked induced pluripotent cancer cells (iPCs) established previously do not possess mutations known in the parental population. This unanticipated observation is most parsimoniously explained by the Elite model, whereby putative early tumor progenies were selected during induction to pluripotency. © 2013 Lai et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/166201
ISSN: 19326203
DOI: 10.1371/journal.pone.0056702
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