Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0096532
DC Field | Value | |
---|---|---|
dc.title | Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction | |
dc.contributor.author | Mien I.H. | |
dc.contributor.author | Chua E.C.-P. | |
dc.contributor.author | Lau P. | |
dc.contributor.author | Tan L.-C. | |
dc.contributor.author | Lee I.T.-G. | |
dc.contributor.author | Yeo S.-C. | |
dc.contributor.author | Tan S.S. | |
dc.contributor.author | Gooley J.J. | |
dc.date.accessioned | 2020-03-26T06:42:30Z | |
dc.date.available | 2020-03-26T06:42:30Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Mien I.H., Chua E.C.-P., Lau P., Tan L.-C., Lee I.T.-G., Yeo S.-C., Tan S.S., Gooley J.J. (2014). Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction. PLoS ONE 9 (5) : e96532. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0096532 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/165952 | |
dc.description.abstract | Exposure to light is a major determinant of sleep timing and hormonal rhythms. The role of retinal cones in regulating circadian physiology remains unclear, however, as most studies have used light exposures that also activate the photopigment melanopsin. Here, we tested the hypothesis that exposure to alternating red light and darkness can enhance circadian resetting responses in humans by repeatedly activating cone photoreceptors. In a between-subjects study, healthy volunteers (n = 24, 21-28 yr) lived individually in a laboratory for 6 consecutive days. Circadian rhythms of melatonin, cortisol, body temperature, and heart rate were assessed before and after exposure to 6 h of continuous red light (631 nm, 13 log photons cm -2 s -1 ), intermittent red light (1 min on/off), or bright white light (2,500 lux) near the onset of nocturnal melatonin secretion (n = 8 in each group). Melatonin suppression and pupillary constriction were also assessed during light exposure. We found that circadian resetting responses were similar for exposure to continuous versus intermittent red light (P = 0.69), with an average phase delay shift of almost an hour. Surprisingly, 2 subjects who were exposed to red light exhibited circadian responses similar in magnitude to those who were exposed to bright white light. Red light also elicited prolonged pupillary constriction, but did not suppress melatonin levels. These findings suggest that, for red light stimuli outside the range of sensitivity for melanopsin, cone photoreceptors can mediate circadian phase resetting of physiologic rhythms in some individuals. Our results also show that sensitivity thresholds differ across non-visual light responses, suggesting that cones may contribute differentially to circadian resetting, melatonin suppression, and the pupillary light reflex during exposure to continuous light. © 2014 Ho Mien et al. | |
dc.publisher | Public Library of Science | |
dc.source | Unpaywall 20200320 | |
dc.subject | hydrocortisone | |
dc.subject | melatonin | |
dc.subject | hydrocortisone | |
dc.subject | melatonin | |
dc.subject | adult | |
dc.subject | article | |
dc.subject | body temperature | |
dc.subject | circadian rhythm | |
dc.subject | continuous light exposure | |
dc.subject | controlled study | |
dc.subject | heart rate | |
dc.subject | hormone metabolism | |
dc.subject | hormone release | |
dc.subject | human | |
dc.subject | human experiment | |
dc.subject | intermittent light exposure | |
dc.subject | light dark cycle | |
dc.subject | light exposure | |
dc.subject | male | |
dc.subject | melatonin suppression | |
dc.subject | normal human | |
dc.subject | pupil reflex | |
dc.subject | pupillary constriction | |
dc.subject | red light | |
dc.subject | retina cone | |
dc.subject | saliva level | |
dc.subject | sensitivity analysis | |
dc.subject | spectral sensitivity | |
dc.subject | stimulus response | |
dc.subject | visual stimulation | |
dc.subject | visual threshold | |
dc.subject | circadian rhythm | |
dc.subject | metabolism | |
dc.subject | photostimulation | |
dc.subject | physiology | |
dc.subject | pupil | |
dc.subject | radiation response | |
dc.subject | Adult | |
dc.subject | Body Temperature | |
dc.subject | Circadian Rhythm | |
dc.subject | Heart Rate | |
dc.subject | Humans | |
dc.subject | Hydrocortisone | |
dc.subject | Male | |
dc.subject | Melatonin | |
dc.subject | Photic Stimulation | |
dc.subject | Pupil | |
dc.subject | Retinal Cone Photoreceptor Cells | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1371/journal.pone.0096532 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 9 | |
dc.description.issue | 5 | |
dc.description.page | e96532 | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1371_journal_pone_0096532.pdf | 607.72 kB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.