Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0098248
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dc.titleA prospective study of romanian agriculture workers for zoonotic influenza infections
dc.contributor.authorComan A.
dc.contributor.authorMaftei D.N.
dc.contributor.authorKrueger W.S.
dc.contributor.authorHeil G.L.
dc.contributor.authorChereches R.M.
dc.contributor.authorSirlincan E.
dc.contributor.authorBria P.
dc.contributor.authorDragnea C.
dc.contributor.authorKasler I.
dc.contributor.authorValentine M.A.
dc.contributor.authorGray G.C.
dc.date.accessioned2020-03-26T06:41:49Z
dc.date.available2020-03-26T06:41:49Z
dc.date.issued2014
dc.identifier.citationComan A., Maftei D.N., Krueger W.S., Heil G.L., Chereches R.M., Sirlincan E., Bria P., Dragnea C., Kasler I., Valentine M.A., Gray G.C. (2014). A prospective study of romanian agriculture workers for zoonotic influenza infections. PLoS ONE 9 (5) : e98248. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0098248
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165948
dc.description.abstractBackground: In this prospective study we sought to examine seroepidemiological evidence for acute zoonotic influenza virus infection among Romanian agricultural workers. Methods: Sera were drawn upon enrollment (2009) and again at 12 and 24 months from 312 adult agriculture workers and 51 age-group matched controls. Participants were contacted monthly for 24 months and queried regarding episodes of acute influenza-like illnesses (ILI). Cohort members meeting ILI criteria permitted respiratory swab collections as well as acute and convalescent serum collection. Serologic assays were performed against 9 avian, 3 swine, and 3 human influenza viruses. Results: During the two-year follow-up, a total of 23 ILI events were reported. Two subjects' specimens were identified as influenza A by rRT-PCR. During the follow-up period, three individuals experienced elevated microneutralization antibody titers ?1:80 against three (one each) avian influenza viruses: A/Teal/Hong Kong/w312/97(H6N1), A/Hong Kong/1073/1999(H9N2), or A/Duck/Alberta/60/ 1976(H12N5). However, none of these participants met the criteria for poultry exposure. A number of subjects demonstrated four-fold increases over time in hemagglutination inhibition (HI) assay titers for at least one of the three swine influenza viruses (SIVs); however, it seems likely that two of these three responses were due to crossreacting antibody against human influenza. Only elevated antibody titers against A/Swine/Flanders/1/1998(H3N2) lacked evidence for such confounding. In examining risk factors for elevated antibody against this SIV with multiple logistic regression, swine exposure (adjusted OR = 1.8, 95% CI 1.1-2.8) and tobacco use (adjusted OR = 1.8; 95% CI 1.1-2.9) were important predictors. Conclusions: While Romania has recently experienced multiple incursions of highly pathogenic avian influenza among domestic poultry, this cohort of Romanian agriculture workers had sparse evidence of avian influenza virus infections. In contrast, there was evidence, especially among the swine exposed participants, of infections with human and one swine H3N2 influenza virus. © 2014 Coman et al.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectagricultural worker
dc.subjectantibody titer
dc.subjectarticle
dc.subjectavian influenza virus
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectfollow up
dc.subjecthemagglutination inhibition
dc.subjecthuman
dc.subjectinfluenza
dc.subjectinfluenza A
dc.subjectmajor clinical study
dc.subjectnonhuman
dc.subjectPiacenzian
dc.subjectprospective study
dc.subjectreverse transcription polymerase chain reaction
dc.subjectrisk factor
dc.subjectseroepidemiology
dc.subjectserology
dc.subjectsmoking
dc.subjectswine influenza virus
dc.subjectvirus detection
dc.subjectAgricultural Workers' Diseases
dc.subjectanimal
dc.subjectcohort analysis
dc.subjectgenetics
dc.subjecthemagglutination inhibition test
dc.subjectInfluenza virus A
dc.subjectInfluenza, Human
dc.subjectreal time polymerase chain reaction
dc.subjectrisk
dc.subjectRomania
dc.subjectserodiagnosis
dc.subjectvirology
dc.subjectZoonoses
dc.subjectAgricultural Workers' Diseases
dc.subjectAnimals
dc.subjectCohort Studies
dc.subjectHemagglutination Inhibition Tests
dc.subjectHumans
dc.subjectInfluenza A virus
dc.subjectInfluenza, Human
dc.subjectNeutralization Tests
dc.subjectOdds Ratio
dc.subjectProspective Studies
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectRomania
dc.subjectSeroepidemiologic Studies
dc.subjectZoonoses
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0098248
dc.description.sourcetitlePLoS ONE
dc.description.volume9
dc.description.issue5
dc.description.pagee98248
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