Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0191609
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dc.title | A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men | |
dc.contributor.author | Rizi E.P. | |
dc.contributor.author | Loh T.P. | |
dc.contributor.author | Baig S. | |
dc.contributor.author | Chhay V. | |
dc.contributor.author | Huang S. | |
dc.contributor.author | Quek J.C. | |
dc.contributor.author | Tai E.S. | |
dc.contributor.author | Toh S.-A. | |
dc.contributor.author | Khoo C.M. | |
dc.date.accessioned | 2020-03-23T06:23:15Z | |
dc.date.available | 2020-03-23T06:23:15Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Rizi E.P., Loh T.P., Baig S., Chhay V., Huang S., Quek J.C., Tai E.S., Toh S.-A., Khoo C.M. (2018). A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men. PLoS ONE 13 (1) : e0191609. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0191609 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/165912 | |
dc.description.abstract | It is known that the macronutrient content of a meal has different impacts on the postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses is not well characterized. We examined the postprandial appetite and satiety hormonal responses after a high-protein (HP), high-carbohydrate (HC), or high-fat (HF) mixed meal. This was a randomized cross-over study of 9 lean insulin-sensitive (mean ±SEM HOMA-IR 0.83±0.10) and 9 obese insulin-resistant (HOMA-IR 4.34±0.41) young (age 21–40 years), normoglycaemic Chinese men. We measured fasting and postprandial plasma concentration of glucose, insulin, active glucagon-like peptide-1 (GLP-1), total peptide-YY (PYY), and acyl-ghrelin in response to HP, HF, or HC meals. Overall postprandial plasma insulin response was more robust in the lean compared to obese subjects. The postprandial GLP-1 response after HF or HP meal was higher than HC meal in both lean and obese subjects. In obese subjects, HF meal induced higher response in postprandial PYY compared to HC meal. HP and HF meals also suppressed ghrelin greater compared to HC meal in the obese than lean subjects. In conclusion, a high-protein or high-fat meal induces a more favorable postprandial satiety and appetite hormonal response than a high-carbohydrate meal in obese insulin-resistant subjects. © 2018 Parvaresh Rizi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.publisher | Public Library of Science | |
dc.source | Unpaywall 20200320 | |
dc.subject | acyl ghrelin | |
dc.subject | carbohydrate | |
dc.subject | ghrelin | |
dc.subject | glucagon like peptide 1 | |
dc.subject | glucose | |
dc.subject | insulin | |
dc.subject | lipid | |
dc.subject | peptide YY | |
dc.subject | protein | |
dc.subject | unclassified drug | |
dc.subject | ghrelin | |
dc.subject | glucagon like peptide 1 | |
dc.subject | insulin | |
dc.subject | peptide YY | |
dc.subject | adult | |
dc.subject | appetite | |
dc.subject | Article | |
dc.subject | carbohydrate diet | |
dc.subject | Chinese | |
dc.subject | clinical article | |
dc.subject | controlled study | |
dc.subject | glucose blood level | |
dc.subject | hormone response | |
dc.subject | human | |
dc.subject | insulin blood level | |
dc.subject | insulin resistance | |
dc.subject | insulin sensitivity | |
dc.subject | lipid diet | |
dc.subject | male | |
dc.subject | obesity | |
dc.subject | postprandial state | |
dc.subject | protein diet | |
dc.subject | satiety | |
dc.subject | administration and dosage | |
dc.subject | Asian continental ancestry group | |
dc.subject | blood | |
dc.subject | carbohydrate diet | |
dc.subject | crossover procedure | |
dc.subject | diet therapy | |
dc.subject | fat intake | |
dc.subject | lipid diet | |
dc.subject | metabolism | |
dc.subject | physiology | |
dc.subject | postprandial state | |
dc.subject | protein diet | |
dc.subject | protein intake | |
dc.subject | randomized controlled trial | |
dc.subject | satiety response | |
dc.subject | Singapore | |
dc.subject | young adult | |
dc.subject | Adult | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | Blood Glucose | |
dc.subject | Cross-Over Studies | |
dc.subject | Diet, High-Fat | |
dc.subject | Diet, High-Protein | |
dc.subject | Dietary Carbohydrates | |
dc.subject | Dietary Fats | |
dc.subject | Dietary Proteins | |
dc.subject | Ghrelin | |
dc.subject | Glucagon-Like Peptide 1 | |
dc.subject | Humans | |
dc.subject | Insulin | |
dc.subject | Insulin Resistance | |
dc.subject | Male | |
dc.subject | Obesity | |
dc.subject | Peptide YY | |
dc.subject | Postprandial Period | |
dc.subject | Satiety Response | |
dc.subject | Singapore | |
dc.subject | Young Adult | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1371/journal.pone.0191609 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 13 | |
dc.description.issue | 1 | |
dc.description.page | e0191609 | |
Appears in Collections: | Elements Students Publications Staff Publications |
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