Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0194209
Title: Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a nonhuman primate model
Authors: Williams G.P.
Wu B.
Liu Y.C. 
Teo E.
Nyein C.L.
Peh G. 
Tan D.T. 
Mehta J.S. 
Keywords: animal
disease model
human
hypermetropia
keratomileusis
lens
Macaca fascicularis
pathology
procedures
Animals
Disease Models, Animal
Humans
Hyperopia
Keratomileusis, Laser In Situ
Lens, Crystalline
Macaca fascicularis
Issue Date: 2018
Publisher: Public Library of Science
Citation: Williams G.P., Wu B., Liu Y.C., Teo E., Nyein C.L., Peh G., Tan D.T., Mehta J.S. (2018). Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a nonhuman primate model. PLoS ONE 13 (3) : e0194209. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0194209
Abstract: Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27?m LASIK, -45 ± 18?m SMILE and 28 ± 17?m Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted. © 2018 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165905
ISSN: 19326203
DOI: 10.1371/journal.pone.0194209
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