Please use this identifier to cite or link to this item:
|Title:||Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a nonhuman primate model||Authors:||Williams G.P.
Disease Models, Animal
Keratomileusis, Laser In Situ
|Issue Date:||2018||Publisher:||Public Library of Science||Citation:||Williams G.P., Wu B., Liu Y.C., Teo E., Nyein C.L., Peh G., Tan D.T., Mehta J.S. (2018). Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a nonhuman primate model. PLoS ONE 13 (3) : e0194209. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0194209||Abstract:||Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27?m LASIK, -45 ± 18?m SMILE and 28 ± 17?m Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted. © 2018 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.||Source Title:||PLoS ONE||URI:||https://scholarbank.nus.edu.sg/handle/10635/165905||ISSN:||19326203||DOI:||10.1371/journal.pone.0194209|
|Appears in Collections:||Elements|
Show full item record
Files in This Item:
|10_1371_journal_pone_0194209.pdf||13.55 MB||Adobe PDF|
checked on Nov 27, 2021
checked on Nov 18, 2021
checked on Nov 18, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.