Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0204996
Title: The relationship between anogenital HPV types and incident HIV infection among men who have sex with men and transgender women in Lima, Peru: Findings from a prospective cohort study
Authors: Brown B.
Marg L.
Leon S.
Chen C. 
Siu J.N.Y.
Calvo G.
Sanchez H.
Galea J.T.
Keywords: Wart virus vaccine
adult
Article
attitude to health
cohort analysis
comorbidity
controlled study
disease association
female
follow up
genotype
homosexual male
human
Human immunodeficiency virus infection
incidence
major clinical study
male
male to female transgender
men who have sex with men and women
mixed infection
papillomavirus infection
Peru
Peruvian
physical examination
prospective study
questionnaire
risk factor
self concept
sexual behavior
Wart virus
adolescent
anal canal
genital system
Human immunodeficiency virus infection
incidence
isolation and purification
male homosexuality
Papillomaviridae
physiology
transgender
virology
young adult
Adolescent
Adult
Anal Canal
Cohort Studies
Female
Genitalia
HIV Infections
Homosexuality, Male
Humans
Incidence
Male
Papillomaviridae
Peru
Prospective Studies
Transgender Persons
Young Adult
Issue Date: 2018
Publisher: Public Library of Science
Citation: Brown B., Marg L., Leon S., Chen C., Siu J.N.Y., Calvo G., Sanchez H., Galea J.T. (2018). The relationship between anogenital HPV types and incident HIV infection among men who have sex with men and transgender women in Lima, Peru: Findings from a prospective cohort study. PLoS ONE 13 (10) : e0204996. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0204996
Abstract: Although it is known that individuals living with HIV have a higher HPV prevalence, the impact of individual HPV types on HIV acquisition is less clear. In this prospective cohort study we investigated the relationship between HPV types and incident HIV infection among men who have sex with men (MSM) and transgender women (TW) in Lima, Peru. Six hundred HIV-negative Peruvian MSM and TW participated in a 2-year study with biannual visits. At baseline, participants completed a computerized, self-administered questionnaire on sexual behavior and HPV knowledge and underwent a physical exam including anogenital swabs for HPV DNA (37 genotypes via linear array testing) and HIV testing; follow-up visits included the questionnaire and HIV testing. Participant mean age was 25 years (range = 18-40), with 48.9% self-identifying as gay and 86.5% reporting having sex exclusively with men. At baseline, 530 participants had HPV DNA present (61.1% with high-risk HPV, 84.9% with low-risk HPV). Among 571 participants who returned for any study visit, 73 (12.8%) became infected with HIV during the 2-year follow-up (6% HIV incidence). Compared to those without HIV, more participants with HIV had any HPV type present (97.3% vs. 87.6%, respectively, p = .01), more than one HPV type (79.5% vs. 58.2%, p < .01), or high-risk HPV (72.6% vs. 51.4%, p < .01). Some participants lost to follow-up could have been HIV-positive, which would have affected the relationship of HPV and HIV infection. Our prospective study showed that participants with any HPV type, more than one HPV type, or high-risk HPV were more likely to test positive for HIV. Although most studies have shown HPV-HIV coinfection, our findings illustrate the strong relationship between individual HPV types and HIV infection. This further illustrates the potential utility of HPV vaccine for MSM and TW, not only for HPV prevention but also possibly for HIV prevention. © 2018 Brown et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165894
ISSN: 19326203
DOI: 10.1371/journal.pone.0204996
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1371_journal_pone_0204996.pdf1.21 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

16
checked on May 28, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.