Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/16586
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dc.titleBiomimetic Nanofiber/Stem Cell Composite for Skin Graft Application
dc.contributor.authorMA KUN
dc.date.accessioned2010-04-08T11:06:47Z
dc.date.available2010-04-08T11:06:47Z
dc.date.issued2009-07-31
dc.identifier.citationMA KUN (2009-07-31). Biomimetic Nanofiber/Stem Cell Composite for Skin Graft Application. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/16586
dc.description.abstractThis study hypothesized that biomimetic nanofiber scaffolds (NFS) functionalized with rich attachment of bone marrow-derived mesenchymal stem cells (BM-MSCs) can promote wound healing in acute full-thickness skin wounds which are not adequately addressed by current clinical treatments. The epidermal differentiation potential of human BM-MSCs was confirmed and achieved by manipulating the biochemical, environmental and physical cues in 3D organotypic coculture. Both NFS and BM-MSCs were found to contribute to the wound healing process in acute full-thickness skin wounds in a rat model. Biodegradable electrospun NFS improved wound healing by providing a provisional matrix for cellular invasion and adhesion, collagen synthesis and deposition. BM-MSCs were found to promote epithelial edge ingrowth, participate in epidermal differentiation and collagen synthesis. This study suggests the potential of using NFS/BM-MSCs composites as skin grafts for the treatment of acute full-thickness skin wounds.
dc.language.isoen
dc.subjectBone marrow-derived mesenchymal stem cells, Nanofiber, Epidermal differentiation, Organotypic coculture, Wound healing, Rat model
dc.typeThesis
dc.contributor.departmentNUS GRAD SCH FOR INTEGRATIVE SCI & ENGG
dc.contributor.supervisorSEERAM RAMAKRISHNA
dc.contributor.supervisorCHAN KWAN-HO, CASEY
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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