Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/165807
Title: Longitudinal Community-Based Study of QT Interval and Mortality in Southeast Asians
Authors: Yap J.
Jin A.Z. 
Nyunt S.Z. 
Ng T.P. 
Richards A.M. 
Lam C.S. 
Keywords: aged
cardiovascular disease
electrocardiography
female
human
Kaplan Meier method
long QT syndrome
male
mortality
Myocardial Infarction
proportional hazards model
prospective study
risk factor
sex difference
Singapore
Stroke
Aged
Cardiovascular Diseases
Electrocardiography
Female
Humans
Kaplan-Meier Estimate
Long QT Syndrome
Male
Myocardial Infarction
Proportional Hazards Models
Prospective Studies
Risk Factors
Sex Factors
Singapore
Stroke
Issue Date: 2016
Publisher: Public Library of Science
Citation: Yap J., Jin A.Z., Nyunt S.Z., Ng T.P., Richards A.M., Lam C.S. (2016). Longitudinal Community-Based Study of QT Interval and Mortality in Southeast Asians. PloS one 11 (5) : e0154901. ScholarBank@NUS Repository.
Abstract: INTRODUCTION: The prognostic impact of QT interval prolongation has not been well studied in healthy Asians. We investigated the association between the QT interval with mortality and cardiovascular events in a healthy Southeast Asian population.METHODS: The QT interval corrected for heart rate using the Bazett's formula (QTc) was measured in 2536 (825 men, mean age 65.7±7.5 years) Singaporean adults free of cardiovascular disease in the population-based Singapore Longitudinal Ageing Study. Outcomes were all-cause mortality and incident cardiovascular events (cardiovascular mortality, myocardial infarction (MI) and/or stroke).RESULTS: Over a mean 7.78 years (19695 person-years) of follow-up, there were 202 deaths (45 from cardiovascular causes), 62 cases of myocardial infarction and 64 cases of stroke. Adjusting for age, sex, and cardiovascular risk factors, QTcB prolongation remained independently associated with increased all-cause mortality (HR(per standard deviation) 1.27 (1.10-1.48), p = 0.0015), as well as increased risk of cardiovascular events (HR 1.20 (1.01-1.43), p = 0.0415) and MI/stroke (HR 1.22 (1.01-1.47), p = 0.0455), but not cardiovascular mortality alone (HR 1.05 (0.77-1.44), p = 0.7562).CONCLUSIONS: We provide the first community-based estimates of the independent association of QT prolongation with all-cause mortality and cardiovascular events in Southeast Asians.
Source Title: PloS one
URI: https://scholarbank.nus.edu.sg/handle/10635/165807
ISSN: 19326203
Appears in Collections:Staff Publications

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