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Title: Gender-differences in the associations between circulating creatine kinase, blood pressure, body mass and non-alcoholic fatty liver disease in asymptomatic asians
Authors: Yen C.-H.
Wang K.-T.
Lee P.-Y.
Liu C.-C.
Hsieh Y.-C.
Kuo J.-Y.
Bulwer B.E.
Hung C.-L.
Chang S.-C.
Shih S.-C.
Hu K.-C.
Yeh H.-I.
Lam C.S.P. 
Keywords: creatine kinase
creatine kinase
blood pressure
body mass
clinical feature
controlled study
creatine kinase blood level
diastolic blood pressure
estimated glomerular filtration rate
fat mass
major clinical study
nonalcoholic fatty liver
pulse pressure
sex difference
systolic blood pressure
waist circumference
Asian continental ancestry group
glomerulus filtration rate
middle aged
nonalcoholic fatty liver
Asian Continental Ancestry Group
Blood Pressure
Body Mass Index
Creatine Kinase
Glomerular Filtration Rate
Middle Aged
Non-alcoholic Fatty Liver Disease
Sex Factors
Issue Date: 2017
Publisher: Public Library of Science
Citation: Yen C.-H., Wang K.-T., Lee P.-Y., Liu C.-C., Hsieh Y.-C., Kuo J.-Y., Bulwer B.E., Hung C.-L., Chang S.-C., Shih S.-C., Hu K.-C., Yeh H.-I., Lam C.S.P. (2017). Gender-differences in the associations between circulating creatine kinase, blood pressure, body mass and non-alcoholic fatty liver disease in asymptomatic asians. PLoS ONE 12 (6) : e0179898. ScholarBank@NUS Repository.
Abstract: Background Creatine kinase (CK) is a pivotal regulatory enzyme in energy metabolism linked to both blood pressure and cardio-metabolic components. However, data is lacking in a large population of asymptomatic Asians. Methods and results Cardio-metabolic assessment including anthropometric measures and non-alcoholic fatty liver disease (NAFLD) were evaluated by abdominal echo in 4,562 consecutive subjects who underwent an annual health survey. Serum CK levels were related to blood pressure components [systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP)], anthropometric measures, and excessive adiposity in liver as indicated by NAFLD. Circulating CK levels ranged from 4 to 1842 IU/L (mean [SE]: 108.7 [1.1] IU/L) in the study population which consisted of 2522 males (mean age: 48.7 ± 11.2) and 2040 females (mean age: 49.4±11.5). In general, male subjects presented with higher circulating CK levels than females (mean ± SE: 127.3 ± 1.5 vs. 85.5 ± 1.3 IU/L, respectively, p .001). Gender-differences in circulating CK levels were also observed with increasing age, which showed a more pronounced positive relationship with age in female subjects (gender interaction: p .05). Furthermore, an elevated circulating CK level was independently associated with higher blood pressure, waist circumference and fat mass (FM), greater body mass index (BMI), increased lower estimated glomerular filtration rate (eGFR) and presence of NAFLD in multivariate analysis (all p .05), with CK elevation more pronounced with greater BMI and FM in males compared with females (sex interaction: p .05). Conclusion In a large asymptomatic Asian population, circulating CK levels were increased with more advanced age, higher blood pressure, and greater body mass with gender differences. Our findings may be useful in interpreting elevated CK from subjects free of ongoing myocardial damage. © 2017 Yen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0179898
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