Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0180818
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dc.titleAge-dependent relationships between body mass index and mortality: Singapore longitudinal ageing study
dc.contributor.authorNg T.P.
dc.contributor.authorJin A.
dc.contributor.authorChow K.Y.
dc.contributor.authorFeng L.
dc.contributor.authorNyunt M.S.Z.
dc.contributor.authorYap K.B.
dc.date.accessioned2020-03-19T09:01:03Z
dc.date.available2020-03-19T09:01:03Z
dc.date.issued2017
dc.identifier.citationNg T.P., Jin A., Chow K.Y., Feng L., Nyunt M.S.Z., Yap K.B. (2017). Age-dependent relationships between body mass index and mortality: Singapore longitudinal ageing study. PLoS ONE 12 (7) : e0180818. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0180818
dc.identifier.issn1932-6203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165783
dc.description.abstractObjectives: The relationship between body mass index (BMI) with mortality risk, in particular the BMI category associated with the lowest all-cause and CVD-and-stroke mortality and the BMI threshold for defining overweight or obesity in older persons is controversial. This study investigated the age-dependent associations of BMI categories with all-cause and cardiovascular disease (CVD) and stroke mortality. Method: Prospective cohort study (Singapore Longitudinal Ageing Studies) of older adults aged 55 and above, followed up from 2003 to 2011. Participants were 2605 Chinese with baseline BMI and other variables. Outcome Measurement: Mortality hazard ratios (HR) for all-cause and CVD and stroke mortality. Results: Overall, BMI showed a U-shaped relationship with all-cause and CVD and stroke mortality, being lowest at Normal Weight-II category (BMI 23.0–24.9 kg/m2). Most evidently among the middle-aged (55–64 years), all-cause mortality risks relative to Normal Weight-II were elevated for underweight (<BMI 18.5; HR = 4.92, p<0.0138), Normal Weight-I (BMI 18.5–22.9; HR = 3.41, p = 0.0149), and Overweight-Obese (BMI>30.0; HR = 4.05,p = 0.0423). Among the old (65 years), however, Overweight and Obese categories were not significantly associated with increased all-cause mortality (HR from 0.98 to 1.29), but Overweight-Obese was associated with increased CVD and stroke mortality (HR = 10.0, p = 0.0086). Conclusion: BMI showed a U-shaped relationship with mortality. Among older persons aged 65 and above, the overweight-or-obese category of BMI was not associated with excess all-cause mortality. © 2017 Ng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectadult
dc.subjectage
dc.subjectage distribution
dc.subjectaged
dc.subjectall cause mortality
dc.subjectArticle
dc.subjectbody mass
dc.subjectbody weight
dc.subjectcardiovascular disease
dc.subjectcardiovascular mortality
dc.subjectcerebrovascular accident
dc.subjectChinese
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectlongitudinal study
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectobesity
dc.subjectprospective study
dc.subjectSingapore
dc.subjectunderweight
dc.subjectbody mass
dc.subjectcause of death
dc.subjectcomplication
dc.subjectfollow up
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectphysiology
dc.subjectproportional hazards model
dc.subjectrisk factor
dc.subjecttrends
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBody Mass Index
dc.subjectBody Weight
dc.subjectCardiovascular Diseases
dc.subjectCause of Death
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMortality
dc.subjectObesity
dc.subjectOverweight
dc.subjectProportional Hazards Models
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.subjectSingapore
dc.subjectThinness
dc.typeArticle
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF PSYCHOLOGICAL MEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0180818
dc.description.sourcetitlePLoS ONE
dc.description.volume12
dc.description.issue7
dc.description.pagee0180818
dc.published.statePublished
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