Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0106751
Title: High rate of A(H1N1)pdm09 infections among rural Thai villagers, 2009-2010
Authors: Khuntirat B.
Yoon I.-K.
Chittaganpitch M.
Krueger W.S.
Supawat K.
Blair P.J.
Putnam S.D.
Gibbons R.V.
Buddhari D.
Sawanpanyalert P.
Heil G.L.
Friary J.A.
Gray G.C. 
Keywords: 2009 H1N1 influenza
adult
age distribution
Article
blood sampling
cohort analysis
controlled study
convalescence
disease surveillance
female
flu like syndrome
hemagglutination inhibition test
household
human
incidence
infection rate
infection risk
longitudinal study
major clinical study
male
mortality
prospective study
reverse transcription polymerase chain reaction
risk assessment
rural population
secondary infection
seroconversion
seroprevalence
Thai (people)
virus transmission
adolescent
aged
asymptomatic infection
child
family size
infant
Influenza A virus (H1N1)
Influenza, Human
middle aged
pandemic
pathogenicity
pathophysiology
physiology
preschool child
Thailand
transmission
Orthomyxoviridae
Adolescent
Adult
Aged
Asymptomatic Infections
Child
Child, Preschool
Family Characteristics
Female
Hemagglutination Inhibition Tests
Humans
Incidence
Infant
Influenza A Virus, H1N1 Subtype
Influenza, Human
Male
Middle Aged
Pandemics
Prospective Studies
Rural Population
Thailand
Issue Date: 2014
Publisher: Public Library of Science
Citation: Khuntirat B., Yoon I.-K., Chittaganpitch M., Krueger W.S., Supawat K., Blair P.J., Putnam S.D., Gibbons R.V., Buddhari D., Sawanpanyalert P., Heil G.L., Friary J.A., Gray G.C. (2014). High rate of A(H1N1)pdm09 infections among rural Thai villagers, 2009-2010. PLoS ONE 9 (9) : e106751. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0106751
Abstract: Background: Pandemic influenza A(H1N1)pdm09 emerged in Thailand in 2009. A prospective longitudinal adult cohort and household transmission study of influenza-like illness (ILI) was ongoing in rural Thailand at the time of emergence. Symptomatic and subclinical A(H1N1)pdm09 infection rates in the cohort and among household members were evaluated. Methods: A cohort of 800 Thai adults underwent active community-based surveillance for ILI from 2008-2010. Acute respiratory samples from ILI episodes were tested for A(H1N1)pdm09 by qRT-PCR; acute and 60-day convalescent blood samples were tested by A(H1N1)pdm09 hemagglutination inhibition assay (HI). Enrollment, 12-month and 24-month follow-up blood samples were tested for A(H1N1)pdm09 seroconversion by HI. Household members of influenza A-infected cohort subjects with ILI were enrolled in household transmission investigations in which day 0 and 60 blood samples and acute respiratory samples were tested by either qRT-PCR or HI for A(H1N1)pdm09. Seroconversion between annual blood samples without A(H1N1)pdm09-positive ILI was considered as subclinical infection. Results: The 2-yr cumulative incidence of A(H1N1)pdm09 infection in the cohort in 2009/2010 was 10.8% (84/781) with an annual incidence of 1.2% in 2009 and 9.7% in 2010; 83.3% of infections were subclinical (50% in 2009 and 85.9% in 2010). The 2-yr cumulative incidence was lowest (5%) in adults born ?1957. The A(H1N1)pdm09 secondary attack rate among household contacts was 47.2% (17/36); 47.1% of these infections were subclinical. The highest A(H1N1)pdm09 secondary attack rate among household contacts (70.6%, 12/17) occurred among children born between 1990 and 2003. Conclusion: Subclinical A(H1N1)pdm09 infections in Thai adults occurred frequently and accounted for a greater proportion of all A(H1N1)pdm09 infections than previously estimated. The role of subclinical infections in A(H1N1)pdm09 transmission has important implications in formulating strategies to predict and prevent the spread of A(H1N1)pdm09 and other influenza virus strains.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165709
ISSN: 19326203
DOI: 10.1371/journal.pone.0106751
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