Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0006163
Title: Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population
Authors: Ang L.W.
Kam Y.W.
Lin C. 
Krishnan P.U.
Tay J.
Ng L.C.
James L.
Lee V.J.M. 
Goh K.T. 
Ng L.F.P. 
Lin R.T.P. 
Keywords: immunoglobulin G
neutralizing antibody
neutralizing antibody
virus antibody
adult
Aedes aegypti
aged
Article
Chikungunya virus
cross-sectional study
Dengue virus
disease surveillance
endemic disease
enzyme linked immunosorbent assay
female
health survey
human
incidence
laboratory test
male
middle aged
nonhuman
seroprevalence
virus detection
young adult
adolescent
blood
chikungunya
Chikungunya virus
epidemic
immunology
risk factor
seroepidemiology
Singapore
Adolescent
Adult
Aged
Antibodies, Neutralizing
Antibodies, Viral
Chikungunya Fever
Chikungunya virus
Cross-Sectional Studies
Dengue Virus
Disease Outbreaks
Female
Humans
Male
Middle Aged
Risk Factors
Seroepidemiologic Studies
Singapore
Young Adult
Issue Date: 2017
Publisher: Public Library of Science
Citation: Ang L.W., Kam Y.W., Lin C., Krishnan P.U., Tay J., Ng L.C., James L., Lee V.J.M., Goh K.T., Ng L.F.P., Lin R.T.P. (2017). Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population. PLoS Neglected Tropical Diseases 11 (12) : e0006163. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0006163
Abstract: Objectives We determined the seroprevalence of chikungunya virus (CHIKV) infection in the adult resident population in Singapore following local outbreaks of chikungunya fever (CHIKF) in 2008–2009. Methods Our cross-sectional study involved residual sera from 3,293 adults aged 18–79 years who had participated in the National Health Survey in 2010. Sera were tested for IgG antibodies against CHIKV and dengue virus (DENV) and neutralizing antibodies against CHIKV. Results The prevalence of CHIKV-neutralizing antibodies among Singapore residents aged 18–79 years was 1.9% (95% confidence interval: 1.4%– 2.3%). The CHIKV seroprevalence was highest in the elderly aged 70–79 years at 11.5%, followed by those aged 30–39 years at 3.1%. Men had significantly higher CHIKV seroprevalence than women (2.5% versus 1.3%, p = 0.01). Among the three main ethnic groups, Indians had the highest seroprevalence (3.5%) compared to Chinese (1.6%) and Malays (0.7%) (p = 0.02 and p = 0.01, respectively). Multivariable logistic regression identified adults aged 30–39 years and 70–79 years, men, those of Indian ethnicity and ethnic minor groups, and residence on ground floor of public and private housing apartments as factors that were significantly associated with a higher likelihood of exposure to CHIKV. The overall prevalence of anti-DENV IgG antibodies was 56.8% (95% CI: 55.1%– 58.5%), while 1.5% (95% CI: 1.1%– 2.0%) of adults possessed both neutralizing antibodies against CHIKV and IgG antibodies against DENV. Conclusions Singapore remains highly susceptible to CHIKV infection. There is a need to maintain a high degree of vigilance through disease surveillance and vector control. Findings from such serological study, when conducted on a regular periodic basis, could supplement surveillance to provide insights on CHIKV circulation in at-risk population. © 2017 Ang et al.
Source Title: PLoS Neglected Tropical Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/165624
ISSN: 19352727
DOI: 10.1371/journal.pntd.0006163
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