Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0019801
Title: Transmission of plasmodium vivax in south-western Uganda: Report of three cases in pregnant women
Authors: Dhorda M.
Nyehangane D.
Rénia L.
Piola P.
Guerin P.J.
Snounou G. 
Keywords: pyrimethamine
adult
antimalarial drug resistance
article
blood group Duffy system
case report
female
gene mutation
human
microorganism detection
microscopy
nonhuman
parasite detection
parasite identification
parasite prevalence
parasite transmission
Plasmodium falciparum
Plasmodium ovale
Plasmodium vivax
Plasmodium vivax malaria
polymerase chain reaction
pregnant woman
Uganda
Africa south of the Sahara
cohort analysis
disease transmission
drug resistance
erythrocyte
genetics
isolation and purification
longitudinal study
parasitology
pathogenicity
Plasmodium vivax
Plasmodium vivax malaria
pregnancy
pregnancy complication
Plasmodium parasites
Plasmodium vivax
Africa South of the Sahara
Cohort Studies
Drug Resistance
Duffy Blood-Group System
Erythrocytes
Female
Humans
Longitudinal Studies
Malaria, Vivax
Plasmodium vivax
Polymerase Chain Reaction
Pregnancy
Pregnancy Complications, Parasitic
Uganda
Issue Date: 2011
Publisher: Public Library of Science
Citation: Dhorda M., Nyehangane D., Rénia L., Piola P., Guerin P.J., Snounou G. (2011). Transmission of plasmodium vivax in south-western Uganda: Report of three cases in pregnant women. PLoS ONE 6 (5) : e19801. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0019801
Abstract: Plasmodium vivax is considered to be rare in the predominantly Duffy negative populations of Sub-Saharan Africa, as this red blood cell surface antigen is essential for invasion by the parasite. However, despite only very few reports of molecularly confirmed P. vivax from tropical Africa, serological evidence indicated that 13% of the persons sampled in Congo had been exposed to P. vivax. We identified P. vivax by microscopy in 8 smears from Ugandan pregnant women who had been enrolled in a longitudinal study of malaria in pregnancy. A nested polymerase chain reaction (PCR) protocol was used to detect and identify the Plasmodium parasites present. PCR analysis confirmed the presence of P. vivax for three of the women and analysis of all available samples from these women revealed clinically silent chronic low-grade vivax infections for two of them. The parasites in one woman carried pyrimethamine resistance-associated double non-synonymous mutations in the P. vivax dihydrofolate reductase gene. The three women found infected with P. vivax were Duffy positive as were nine of 68 women randomly selected from the cohort. The data presented from these three case reports is consistent with stable transmission of malaria in a predominantly Duffy negative African population. Given the substantial morbidity associated with vivax infection in non-African endemic areas, it will be important to investigate whether the distribution and prevalence of P. vivax have been underestimated in Sub-Saharan Africa. This is particularly important in the context of the drive to eliminate malaria and its morbidity. © 2011 Dhorda et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/165591
ISSN: 19326203
DOI: 10.1371/journal.pone.0019801
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