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Title: Function studies on ring proteins in white spot syndrome virus
Authors: HE FANG
Keywords: WSSV,RING,Ubiquitination,TSL,anti-apoptosis,IE1 promoter
Issue Date: 25-Feb-2009
Citation: HE FANG (2009-02-25). Function studies on ring proteins in white spot syndrome virus. ScholarBank@NUS Repository.
Abstract: White Spot Syndrome Virus, Nimaviridiae Whispovirus, is one of the major viral pathogens in the aquaculture industry responsible for high mortality in cultured shrimp. The infection mechanisms of WSSV have not been fully characterized at the molecular level due to the large size and uniqueness of its genome. This study was undertaken to advance our understanding of the specific function of RING-containing proteins in viral pathogenesis.A preliminary search for regulatory protein candidates in WSSV using functional domain determination identified four predicted viral proteins containing a RING-H2 domain. Among them, the three proteins WSSV222, WSSV249 and WSSV403 can be expressed in both E.coli and insect cells, suggesting their potential expression in shrimp. In this study, emphasis has been placed on the characterization of WSSV222 and WSSV403 for viral pathogenesis.
Appears in Collections:Ph.D Theses (Open)

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