Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0002820
Title: Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome, Xinyang, China
Authors: Liu K.
Cui N.
Fang L.-Q.
Wang B.-J.
Lu Q.-B.
Peng W.
Li H.
Wang L.-Y.
Liang S.
Wang H.-Y.
Zhang Y.-Y.
Zhuang L.
Yang H.
Gray G.C. 
de Vlas S.J.
Liu W.
Cao W.-C.
Keywords: adult
aged
article
Bunyavirus
bunyavirus infection
child
China
cropland
environmental factor
epidemic
female
forest
Haemaphysalis longicornis
human
major clinical study
male
morbidity
nonhuman
risk factor
severe fever with thrombocytopenia syndrome
Severe fever with thrombocytopenia syndrome virus
shrub
adolescent
agriculture
Bunyaviridae Infections
incidence
isolation and purification
middle aged
Phlebovirus
Poisson distribution
season
very elderly
virology
young adult
Adolescent
Adult
Aged
Aged, 80 and over
Agriculture
Bunyaviridae Infections
Child
China
Female
Humans
Incidence
Male
Middle Aged
Phlebovirus
Poisson Distribution
Risk Factors
Seasons
Young Adult
Issue Date: 2014
Publisher: Public Library of Science
Citation: Liu K., Cui N., Fang L.-Q., Wang B.-J., Lu Q.-B., Peng W., Li H., Wang L.-Y., Liang S., Wang H.-Y., Zhang Y.-Y., Zhuang L., Yang H., Gray G.C., de Vlas S.J., Liu W., Cao W.-C. (2014). Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome, Xinyang, China. PLoS Neglected Tropical Diseases 8 (5) : e2820. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002820
Abstract: Background:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in rural areas of Central China in 2009, caused by a novel bunyavirus, SFTS virus (SFTSV). The disease usually presents as fever, thrombocytopenia, and leukocytopenia, with case-fatality rates ranging from 2.5% to 30%. Haemaphysalis longicornis was suspected to be the most likely vector of SFTSV. By the end of 2012, the disease had expanded to 13 provinces of China. SFTS patients have been reported in Japan and South Korea, and a disease similar to SFTS has been reported in the United States.Methodology/Principal Findings:We characterized the epidemiologic features of 504 confirmed SFTS cases in Xinyang Region, the most severely SFTS-afflicted region in China from 2011 to 2012, and assessed the environmental risk factors. All cases occurred during March to November, with the epidemic peaking from May to July. The patients' ages ranged from 7 to 87 years (median 61 years), and the annual incidence increased with age (? 2 test for trend, P<0.001). The female-to-male ratio of cases was 1.58, and 97.0% of the cases were farmers who resided in the southern and western parts of the region. The Poisson regression analysis revealed that the spatial variations of SFTS incidence were significantly associated with the shrub, forest, and rain-fed cropland areas.Conclusions:The distribution of SFTS showed highly significant temporal and spatial heterogeneity in Xinyang Region, with the majority of SFTS cases being elderly farmers who resided in the southern and western parts of the region, mostly acquiring infection between May and July when H. longicornis is highly active. The shrub, rain-fed, and rain-fed cropland areas were associated with high risk for this disease. © 2014 Liu et al.
Source Title: PLoS Neglected Tropical Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/165398
ISSN: 19352727
DOI: 10.1371/journal.pntd.0002820
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