Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pgen.1005704
DC Field | Value | |
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dc.title | Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus | |
dc.contributor.author | Zheng W. | |
dc.contributor.author | Zhou J. | |
dc.contributor.author | He Y. | |
dc.contributor.author | Xie Q. | |
dc.contributor.author | Chen A. | |
dc.contributor.author | Zheng H. | |
dc.contributor.author | Shi L. | |
dc.contributor.author | Zhao X. | |
dc.contributor.author | Zhang C. | |
dc.contributor.author | Huang Q. | |
dc.contributor.author | Fang K. | |
dc.contributor.author | Lu G. | |
dc.contributor.author | Ebbole D.J. | |
dc.contributor.author | Li G. | |
dc.contributor.author | Naqvi N.I. | |
dc.contributor.author | Wang Z. | |
dc.date.accessioned | 2020-03-13T05:24:05Z | |
dc.date.available | 2020-03-13T05:24:05Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Zheng W., Zhou J., He Y., Xie Q., Chen A., Zheng H., Shi L., Zhao X., Zhang C., Huang Q., Fang K., Lu G., Ebbole D.J., Li G., Naqvi N.I., Wang Z. (2015). Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus. PLoS Genetics 11 (12) : e1005704. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1005704 | |
dc.identifier.issn | 15537390 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/165389 | |
dc.description.abstract | The retromer mediates protein trafficking through recycling cargo from endosomes to the trans-Golgi network in eukaryotes. However, the role of such trafficking events during pathogen-host interaction remains unclear. Here, we report that the cargo-recognition complex (MoVps35, MoVps26 and MoVps29) of the retromer is essential for appressorium-mediated host penetration by Magnaporthe oryzae, the causal pathogen of the blast disease in rice. Loss of retromer function blocked glycogen distribution and turnover of lipid bodies, delayed nuclear degeneration and reduced turgor during appressorial development. Cytological observation revealed dynamic MoVps35-GFP foci co-localized with autophagy-related protein RFP-MoAtg8 at the periphery of autolysosomes. Furthermore, RFP-MoAtg8 interacted with MoVps35-GFP in vivo, RFP-MoAtg8 was mislocalized to the vacuole and failed to recycle from the autolysosome in the absence of the retromer function, leading to impaired biogenesis of autophagosomes. We therefore conclude that retromer is essential for autophagy-dependent plant infection by the rice blast fungus. © 2015 Zheng et al. | |
dc.publisher | Public Library of Science | |
dc.source | Unpaywall 20200320 | |
dc.subject | fat droplet | |
dc.subject | glycogen | |
dc.subject | amino acid sequence | |
dc.subject | autophagy | |
dc.subject | cell vacuole | |
dc.subject | genetics | |
dc.subject | host pathogen interaction | |
dc.subject | Magnaporthe | |
dc.subject | metabolism | |
dc.subject | microbiology | |
dc.subject | Oryza | |
dc.subject | pathogenicity | |
dc.subject | plant disease | |
dc.subject | plant leaf | |
dc.subject | protein transport | |
dc.subject | trans Golgi network | |
dc.subject | Amino Acid Sequence | |
dc.subject | Autophagy | |
dc.subject | Glycogen | |
dc.subject | Host-Pathogen Interactions | |
dc.subject | Lipid Droplets | |
dc.subject | Magnaporthe | |
dc.subject | Oryza | |
dc.subject | Plant Diseases | |
dc.subject | Plant Leaves | |
dc.subject | Protein Transport | |
dc.subject | trans-Golgi Network | |
dc.subject | Vacuoles | |
dc.type | Article | |
dc.contributor.department | DEPT OF BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1371/journal.pgen.1005704 | |
dc.description.sourcetitle | PLoS Genetics | |
dc.description.volume | 11 | |
dc.description.issue | 12 | |
dc.description.page | e1005704 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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