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Title: Different treatment efficacies and side effects of cytotoxicchemotherapy
Authors: Wang Lingzhi 
Chong Qing Yun 
Goh Boon Cher 
Soo Ross 
Li Low-Jia
Keywords: Lung cancer
Cytotoxic chemotherapy
Issue Date: 13-Aug-2019
Publisher: Pioneer Bioscience Publishing Company (PBPC)
Citation: Wang Lingzhi, Chong Qing Yun, Goh Boon Cher, Soo Ross, Li Low-Jia (2019-08-13). Different treatment efficacies and side effects of cytotoxicchemotherapy. Journal of Thoracic Disease. ScholarBank@NUS Repository.
Abstract: Differences in efficacy and toxicity between Asian and Caucasian patients with lung cancer treated with systemic chemotherapy is increasingly recognised. This is a major concern in the clinical setting as it influences outcomes and affect international harmonization of drug development. Interindividual variability of pharmacokinetics, where different genetic polymorphisms affect drug metabolism, transport, and receptor binding may account for the ethnic differences. Treatment efficacy and outcomes may also be explained by differences in diet and lifestyle, access to healthcare, cultural barriers and environmental exposure. Efforts made to design prospective studies investigating ethnic specific determinants to systemic therapy and individualise lung cancer treatment based on genetic makeup of patient are important.
Source Title: Journal of Thoracic Disease
ISSN: 20721439
DOI: 10.21037/jtd.2019.08.63
Appears in Collections:Staff Publications

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