Please use this identifier to cite or link to this item: https://doi.org/10.1177/154405910408300415
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dc.titleIdentification of RANKL in osteolytic lesions of the facial skeleton
dc.contributor.authorTay, JYY
dc.contributor.authorBay, BH
dc.contributor.authorYeo, JF
dc.contributor.authorHarris, M
dc.contributor.authorMeghji, S
dc.contributor.authorDheen, ST
dc.date.accessioned2020-01-20T06:42:15Z
dc.date.available2020-01-20T06:42:15Z
dc.date.issued2004-04-01
dc.identifier.citationTay, JYY, Bay, BH, Yeo, JF, Harris, M, Meghji, S, Dheen, ST (2004-04-01). Identification of RANKL in osteolytic lesions of the facial skeleton. JOURNAL OF DENTAL RESEARCH 83 (4) : 349-353. ScholarBank@NUS Repository. https://doi.org/10.1177/154405910408300415
dc.identifier.issn00220345
dc.identifier.issn15440591
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/163921
dc.description.abstractRANKL (receptor activator of nuclear factor ?B ligand) promotes osteoclast differentiation, stimulates osteoclast activity, and prolongs osteoclast survival and adherence to bone. Abnormalities of the RANKL/RANK/osteoprotegerin system have been implicated in a range of diseases, including osteoporosis. To date, no work has been done in osteolytic lesions of the facial skeleton. In this study, specimens of ameloblastomas, dentigerous cysts, odontogenic keratocysts, and radicular cysts were subjected to immunohistochemical analysis for RANKL and tartrate-resistant acid phosphatase (TRAP). Immunofluorescence staining for TRAP was visualized under confocal microscopy. All specimens demonstrated distinct positive immunoreactivity to RANKL and TRAP. The TRAP-positive cells also stained with in situ hybridization for human calcitonin receptor, a definitive marker for osteoclasts. Mononuclear pre-osteoclasts were observed to migrate from blood to the connective tissue stroma and multinucleate toward the bone surface. It can be concluded that RANKL plays a role in bone resorption in osteolytic lesions of the facial skeleton.
dc.language.isoen
dc.publisherSAGE PUBLICATIONS
dc.sourceElements
dc.subjectBone resorption
dc.subjectConfocal microscopy
dc.subjectImmunohistochemistry
dc.subjectOsteoclast
dc.subjectRANKL
dc.typeArticle
dc.date.updated2020-01-17T07:55:56Z
dc.contributor.departmentDEPT OF ANATOMY
dc.contributor.departmentDEPT OF DENTISTRY
dc.description.doi10.1177/154405910408300415
dc.description.sourcetitleJOURNAL OF DENTAL RESEARCH
dc.description.volume83
dc.description.issue4
dc.description.page349-353
dc.description.codenJDREA
dc.identifier.isiut000226561400015
dc.description.placeUnited States
dc.published.statePublished
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