Please use this identifier to cite or link to this item: https://doi.org/10.1177/154405910408300415
Title: Identification of RANKL in osteolytic lesions of the facial skeleton
Authors: Tay, JYY
Bay, BH 
Yeo, JF 
Harris, M 
Meghji, S
Dheen, ST 
Keywords: Bone resorption
Confocal microscopy
Immunohistochemistry
Osteoclast
RANKL
Issue Date: 1-Apr-2004
Publisher: SAGE PUBLICATIONS
Citation: Tay, JYY, Bay, BH, Yeo, JF, Harris, M, Meghji, S, Dheen, ST (2004-04-01). Identification of RANKL in osteolytic lesions of the facial skeleton. JOURNAL OF DENTAL RESEARCH 83 (4) : 349-353. ScholarBank@NUS Repository. https://doi.org/10.1177/154405910408300415
Abstract: RANKL (receptor activator of nuclear factor ?B ligand) promotes osteoclast differentiation, stimulates osteoclast activity, and prolongs osteoclast survival and adherence to bone. Abnormalities of the RANKL/RANK/osteoprotegerin system have been implicated in a range of diseases, including osteoporosis. To date, no work has been done in osteolytic lesions of the facial skeleton. In this study, specimens of ameloblastomas, dentigerous cysts, odontogenic keratocysts, and radicular cysts were subjected to immunohistochemical analysis for RANKL and tartrate-resistant acid phosphatase (TRAP). Immunofluorescence staining for TRAP was visualized under confocal microscopy. All specimens demonstrated distinct positive immunoreactivity to RANKL and TRAP. The TRAP-positive cells also stained with in situ hybridization for human calcitonin receptor, a definitive marker for osteoclasts. Mononuclear pre-osteoclasts were observed to migrate from blood to the connective tissue stroma and multinucleate toward the bone surface. It can be concluded that RANKL plays a role in bone resorption in osteolytic lesions of the facial skeleton.
Source Title: JOURNAL OF DENTAL RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/163921
ISSN: 00220345
15440591
DOI: 10.1177/154405910408300415
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