Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/163866
Title: Enhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide
Authors: Lian, QH 
Samuel, TSW 
Dheen, ST 
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
transforming growth factor-beta isoforms
amoeboid microglia
neural tube defects
diabetic embryos
cyclophosphamide
NEPHROPATHY
TGF-BETA-2
RISK
Issue Date: 6-Nov-2003
Publisher: ELSEVIER SCI IRELAND LTD
Citation: Lian, QH, Samuel, TSW, Dheen, ST (2003-11-06). Enhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide. NEUROSCIENCE LETTERS 351 (1) : 51-55. ScholarBank@NUS Repository.
Abstract: We analyzed the expression pattern of transforming growth factor-β isoforms (TGF-β1, TGF-β2 and TGF-β3) in the developing brain of embryos derived from the normal and diabetic mice exposed to cyclophosphamide (CP), a cytotoxic teratogen. The CP-treated diabetic embryos showed significantly more TGF-β1 and TGF-β2 immunoreactive cells in the regions of telencephalon and diencephalon in comparison to that of CP-treated non-diabetic embryos. Moreover, no cells expressing TGF-β isoforms were detectable in the developing brain of normal and diabetic embryos. The mRNA expression levels of TGF-β isoforms were found to be significantly increased in the developing brain of CP-treated diabetic embryos compared to that of CP-treated non-diabetic embryos as measured by quantitative real time reverse transcription-polymerase chain reaction. The enhanced expression levels of TGF-β isoforms appear to be associated with the increased frequency of neural tube defects observed in the diabetic embryos exposed to CP. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: NEUROSCIENCE LETTERS
URI: https://scholarbank.nus.edu.sg/handle/10635/163866
ISSN: 03043940
18727972
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