LOW VALENT METAL COMPLEXES CATALYZED ORGANIC TRANSFORMATIONS (COBALT-CATALYZED ENANTIO-, REGIO- AND STEREOSELECTIVE FUNCTIONALIZATION OF ALKENES AND ALKYNES: METHODOLOGIES AND MECHANISM)

Abstract

Cobalt has emerged as an effective and inexpensive low-valent base metal substitute for precious metals, for unsaturated C-C bond hydrofunctionalization catalysis. They are found abundantly in nature and biological systems. This dissertation describes the use of cobalt coordinated to diimine or bisphosphine ligands as catalysts for the regio-, stereo- and enantioselective synthesis of silyl-, gem-bisboryl- and trisboryl-functionalized compounds through reaction of silanes and boranes with unsaturated C-C bonds. This dissertation also explains the source of high isomeric selectivity resulted from substrate and ligand control, based on careful elucidation of probable mechanistic pathways. In addition, the utility of the functionalized compounds were also displayed by further organic transformations for the synthesis of natural product and their derivatives.