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Title: Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment
Keywords: nasal polyposis, steroid, molecular mechanism
Issue Date: 16-Mar-2009
Citation: LI CHUNWEI (2009-03-16). Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment. ScholarBank@NUS Repository.
Abstract: Nasal polyposis (NP) is a chronic inflammatory airway disease, which represents infiltration of inflammatory cells, epithelial remodeling, and stromal edema. Although glucocorticosteroid (GC) treatment is effective in relieving NP inflammation, the high recurrence rate makes the pathogenesis of NP complicated. We sought to explore the molecular mechanisms underlying NP and its response to GC treatment. At first, we found that the role of superantigen and methylation may be minimal in NP. However, our microarray results revealed that alteration of AP-1 network, anti-inflammatory gene network, apoptosis signaling, complement system, EGF/EGFR signaling, Leukotriene signaling, PGE2 signaling, ERK/MAPK signaling, IL-6 signaling, and NF-kappaB signaling would be involved in the NP pathogenesis. GCs may perform its balance effect on epithelial remodeling in NP via regulation AP-1 network and other pro-/anti-inflammatory genes. Identification of these genes and gene networks ultimately contributes to the knowledge of NP pathogenesis and improvement of NP therapy.
Appears in Collections:Ph.D Theses (Open)

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