Please use this identifier to cite or link to this item: https://doi.org/10.1073/pnas.1900362116
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dc.titleAn initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior
dc.contributor.authorRifkin-Graboi A
dc.contributor.authorTan HM
dc.contributor.authorShaun GKY
dc.contributor.authorSim LW
dc.contributor.authorSanmugam S
dc.contributor.authorChong YS
dc.contributor.authorTan KH
dc.contributor.authorShek L
dc.contributor.authorGluckman PD
dc.contributor.authorChen H
dc.contributor.authorFortier M
dc.contributor.authorMeaney MJ
dc.contributor.authorQiu A
dc.date.accessioned2019-11-27T08:26:09Z
dc.date.available2019-11-27T08:26:09Z
dc.date.issued2019-08-20
dc.identifier.citationRifkin-Graboi A, Tan HM, Shaun GKY, Sim LW, Sanmugam S, Chong YS, Tan KH, Shek L, Gluckman PD, Chen H, Fortier M, Meaney MJ, Qiu A (2019-08-20). An initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior. Proc Natl Acad Sci U S A 116 (34) : 16787-16792. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.1900362116
dc.identifier.issn0027-8424
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/162315
dc.description.abstractAttachment disorganization is a risk factor for difficulties in attention, social relationships, and mental health. Conceptually, attachment disorganization may indicate a breakdown in fear regulation resulting from repeated exposure to frightening maternal care. In addition, past research has examined the influence of stress-inducing contextual factors and/or child factors upon the development of disorganization. However, no past work has assessed whether infant neuroanatomy, important to stress regulation, moderates the association between maternal care and levels of disorganized behavior. Here, utilizing data from a subsample of 82 dyads taking part in the “Growing Up in Singapore towards Healthy Outcomes” (GUSTO) cohort, we assessed the prediction from maternal sensitive caregiving at 6 mo and levels of attachment disorganization at 1.5 y, as moderated by hippocampal and amygdala volume determined within the first 2 weeks of life. Results indicate a significant interaction between neonatal left hippocampal volume and maternal sensitivity upon levels of disorganized behavior. Although these results require substantiation in further research, if replicated, they may enable new strategies for the identification of processes important to child mental health and points for intervention. This is because neonatal neuroanatomy, as opposed to genetic variation and sociodemographic risk, may be more directly linked to stress responses within individuals. © 2019 National Academy of Sciences. All rights reserved.
dc.publisherNational Academy of Sciences
dc.sourceScopus
dc.subjectAmygdala
dc.subjectAttachment disorganization
dc.subjectFear
dc.subjectHippocampus
dc.subjectMaternal sensitivity
dc.typeArticle
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEPT OF PAEDIATRICS
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1073/pnas.1900362116
dc.description.sourcetitleProc Natl Acad Sci U S A
dc.description.volume116
dc.description.issue34
dc.description.page16787-16792
dc.description.codenPNASA
dc.published.statepublished
dc.grant.idNMRC/CBRG/0039/2013
dc.grant.idSPF2013/002
dc.grant.idSICS/YIG/2013/002
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.fundingagencySingapore Institute for Clinical Sciences
dc.grant.fundingagencyAgency for Science, Technology and Research (Singapore)
dc.grant.fundingagencyUniversity of Auckland
dc.grant.fundingagencyNational University of Singapore
dc.grant.fundingagencyField Neurosciences Institute
dc.grant.fundingagencyEnergy Research Institute, Nanyang Technological University
dc.grant.fundingagencyMcGill University
dc.grant.fundingagencyNational Research Foundation Singapore
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
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