Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.clnu.2019.08.018
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dc.titleMaternal night-time eating and sleep duration in relation to length of gestation and preterm birth
dc.contributor.authorLoy SL
dc.contributor.authorCheung YB
dc.contributor.authorCai S
dc.contributor.authorColega MT
dc.contributor.authorGodfrey KM
dc.contributor.authorChong YS
dc.contributor.authorShek LP
dc.contributor.authorTan KH
dc.contributor.authorChong MF
dc.contributor.authorYap F
dc.contributor.authorChan JKY
dc.date.accessioned2019-11-27T08:25:37Z
dc.date.available2019-11-27T08:25:37Z
dc.date.issued2019-08-26
dc.identifier.citationLoy SL, Cheung YB, Cai S, Colega MT, Godfrey KM, Chong YS, Shek LP, Tan KH, Chong MF, Yap F, Chan JKY (2019-08-26). Maternal night-time eating and sleep duration in relation to length of gestation and preterm birth. Clin Nutr. ScholarBank@NUS Repository. https://doi.org/10.1016/j.clnu.2019.08.018
dc.identifier.issn0261-5614
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/162313
dc.description.abstractBackground & aims: Maternal metabolic disturbance arising from inappropriate meal timing or sleep deprivation may disrupt circadian rhythm, potentially inducing pregnancy complications. We examined the associations of maternal night-time eating and sleep duration during pregnancy with gestation length and preterm birth. Methods: We studied 673 pregnant women from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal energy intake by time of day and nightly sleep duration were assessed at 26–28 weeks' gestation. Based on 24-h dietary recall, night-eating was defined as consuming >50% of total energy intake from 1900 to 0659 h. Short sleep duration was defined as <6 h night sleep. Night-eating and short sleep were simultaneously analyzed to examine for associations with a) gestation length using multiple linear regression, and b) preterm birth (<37 weeks' gestation) using logistic regression. Results: Overall, 15.6% women engaged in night-eating, 12.3% had short sleep and 6.8% delivered preterm. Adjusting for confounding factors, night-eating was associated with 0.45 weeks shortening of gestation length (95% CI ?0.75, ?0.16) and 2.19-fold higher odds of delivering preterm (1.01, 4.72). Short sleep was associated with 0.33 weeks shortening of gestation length (?0.66, ?0.01), but its association with preterm birth did not reach statistical significance (1.81; 0.76, 4.30). Conclusions: During pregnancy, women with higher energy consumption at night than during the day had shorter gestation and greater likelihood of delivering preterm. Misalignment of eating time with day–night cycles may be a contributing factor to preterm birth. This points to a potential target for intervention to reduce the risk of preterm birth. Observations for nightly sleep deprivation in relation to gestation length and PTB warrant further confirmation. © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
dc.publisherChurchill Livingstone
dc.sourceScopus
dc.subjectCircadian rhythm
dc.subjectGestation length
dc.subjectMeal timing
dc.subjectPregnancy
dc.subjectPreterm birth
dc.subjectSleep duration
dc.typeArticle in Press
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDEPT OF PAEDIATRICS
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1016/j.clnu.2019.08.018
dc.description.sourcetitleClin Nutr
dc.description.codenCLNUD
dc.published.statepublished
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/CSA(SI)/008/2016
dc.grant.idAsia-573651-EPP-1-2016-1-DE-EPPKA2-CBHE-JP
dc.grant.idNF-SI-0515-10042
dc.grant.idMC_UU_12011/4
dc.grant.fundingagencyDanone
dc.grant.fundingagencyAbbott Laboratories
dc.grant.fundingagencyAgency for Science, Technology and Research (Singapore)
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyEuropean Commission
dc.grant.fundingagencyNational Institute for Health Research
dc.grant.fundingagencyNIHR Imperial Biomedical Research Centre
dc.grant.fundingagencyResearch Councils UK
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
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