Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/16203
DC FieldValue
dc.titleModeling and simulation of antisolvent crystallization: mixing and control
dc.contributor.authorWOO XING YI
dc.date.accessioned2010-04-08T11:02:09Z
dc.date.available2010-04-08T11:02:09Z
dc.date.issued2007-05-25
dc.identifier.citationWOO XING YI (2007-05-25). Modeling and simulation of antisolvent crystallization: mixing and control. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/16203
dc.description.abstractThis dissertation presents the development of simulation tools to address the issues of mixing and control in antisolvent crystallization processes, and to aid the development of systematic and scientific design approaches. The first part presents the development of an algorithm that couples macromixing and micromixing models with the population balance equation. It was applied to simulate antisolvent crystallization in a semibatch stirred vessel and an impinging jet crystallizer. The effects of the operational variables on the crystal size distribution and polymorphic form were numerically investigated. The second part focuses on the theoretical development and analysis of control strategies applied to antisolvent crystallization processes. For semibatch crystallization, the advantage of concentration control over specification of antisolvent addition rate was demonstrated by sensitivity analysis to process disturbances. For impinging jet crystallizers, it is shown that, by coupling with an aging vessel with controlled growth, specific crystal size distributions can be tailored.
dc.language.isoen
dc.subjectAntisolvent crystallization, Computational fluid dynamics, Micromixing, Population balance, Crystal size distribution, Control
dc.typeThesis
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.contributor.supervisorTAN BENG HEE, REGINALD
dc.description.degreePh.D
dc.description.degreeconferredNUS-UIUC JOINT PH.D. PROGRAMME
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
thesisfinal Woo Xing Yi.pdf2.48 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

506
checked on May 18, 2019

Download(s)

966
checked on May 18, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.