Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0032056
Title: Incidence of respiratory virus-associated pneumonia in urban poor young children of dhaka, bangladesh, 2009-2011
Authors: Homaira N.
Luby S.P.
Petri W.A.
Vainionpaa R.
Rahman M.
Hossain K.
Snider C.B.
Rahman M. 
Alamgir A.S.M.
Zesmin F.
Alam M.
Gurley E.S.
Zaman R.U.
Azim T.
Erdman D.D.
Fry A.M.
Bresee J.
Widdowson M.-A.
Haque R.
Azziz-Baumgartner E.
Keywords: Adenovirus
age distribution
article
Bangladesh
child
cohort analysis
controlled study
coughing
disease association
female
follow up
human
Human metapneumovirus
incidence
infant
Influenza virus
longitudinal study
lowest income group
major clinical study
male
nasal lavage
Parainfluenza virus 1
Parainfluenza virus 2
Parainfluenza virus 3
real time reverse transcription polymerase chain reaction
Respiratory syncytial pneumovirus
respiratory tract examination
reverse transcription polymerase chain reaction
Rhinovirus
tachypnea
urban population
viral respiratory tract infection
virus pneumonia
genetics
incidence
Metapneumovirus
methodology
newborn
Orthomyxovirus
Paramyxovirus
poverty
real time polymerase chain reaction
respiratory tract infection
risk factor
virus pneumonia
Human metapneumovirus
Orthomyxoviridae
parainfluenza virus
Respiratory syncytial virus
Rhinovirus
Rice stripe virus
Adenoviridae
Child
Cohort Studies
Humans
Incidence
Infant
Infant, Newborn
Longitudinal Studies
Metapneumovirus
Orthomyxoviridae
Pneumonia, Viral
Poverty
Real-Time Polymerase Chain Reaction
Respiratory Syncytial Viruses
Respiratory Tract Infections
Respirovirus
Rhinovirus
Risk Factors
Urban Population
Issue Date: 2012
Citation: Homaira N., Luby S.P., Petri W.A., Vainionpaa R., Rahman M., Hossain K., Snider C.B., Rahman M., Alamgir A.S.M., Zesmin F., Alam M., Gurley E.S., Zaman R.U., Azim T., Erdman D.D., Fry A.M., Bresee J., Widdowson M.-A., Haque R., Azziz-Baumgartner E. (2012). Incidence of respiratory virus-associated pneumonia in urban poor young children of dhaka, bangladesh, 2009-2011. PLoS ONE 7 (2) : e32056. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0032056
Abstract: Background: Pneumonia is the leading cause of childhood death in Bangladesh. We conducted a longitudinal study to estimate the incidence of virus-associated pneumonia in children aged &2 years in a low-income urban community in Dhaka, Bangladesh. Methods: We followed a cohort of children for two years. We collected nasal washes when children presented with respiratory symptoms. Study physicians diagnosed children with cough and age-specific tachypnea and positive lung findings as pneumonia case-patients. We tested respiratory samples for respiratory syncytial virus (RSV), rhinoviruses, human metapneumovirus (HMPV), influenza viruses, human parainfluenza viruses (HPIV 1, 2, 3), and adenoviruses using real-time reverse transcription polymerase chain reaction assays. Results: Between April 2009-March 2011, we followed 515 children for 730 child-years. We identified a total of 378 pneumonia episodes, 77% of the episodes were associated with a respiratory viral pathogen. The overall incidence of pneumonia associated with a respiratory virus infection was 40/100 child-years. The annual incidence of pneumonia/100 child-years associated with a specific respiratory virus in children aged &2years was 12.5 for RSV, 6 for rhinoviruses, 6 for HMPV, 4 for influenza viruses, 3 for HPIV and 2 for adenoviruses. Conclusion: Young children in Dhaka are at high risk of childhood pneumonia and the majority of these episodes are associated with viral pathogens. Developing effective low-cost strategies for prevention are a high priority.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161998
ISSN: 19326203
DOI: 10.1371/journal.pone.0032056
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