Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.ppat.1005620
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dc.titleEcosystem Interactions Underlie the Spread of Avian Influenza A Viruses with Pandemic Potential
dc.contributor.authorBahl J.
dc.contributor.authorPham T.T.
dc.contributor.authorHill N.J.
dc.contributor.authorHussein I.T.M.
dc.contributor.authorMa E.J.
dc.contributor.authorEasterday B.C.
dc.contributor.authorHalpin R.A.
dc.contributor.authorStockwell T.B.
dc.contributor.authorWentworth D.E.
dc.contributor.authorKayali G.
dc.contributor.authorKrauss S.
dc.contributor.authorSchultz-Cherry S.
dc.contributor.authorWebster R.G.
dc.contributor.authorWebby R.J.
dc.contributor.authorSwartz M.D.
dc.contributor.authorSmith G.J.D.
dc.contributor.authorRunstadler J.A.
dc.date.accessioned2019-11-08T08:44:03Z
dc.date.available2019-11-08T08:44:03Z
dc.date.issued2016
dc.identifier.citationBahl J., Pham T.T., Hill N.J., Hussein I.T.M., Ma E.J., Easterday B.C., Halpin R.A., Stockwell T.B., Wentworth D.E., Kayali G., Krauss S., Schultz-Cherry S., Webster R.G., Webby R.J., Swartz M.D., Smith G.J.D., Runstadler J.A. (2016). Ecosystem Interactions Underlie the Spread of Avian Influenza A Viruses with Pandemic Potential. PLoS Pathogens 12 (5) : e1005620. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1005620
dc.identifier.issn15537366
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161915
dc.description.abstractDespite evidence for avian influenza A virus (AIV) transmission between wild and domestic ecosystems, the roles of bird migration and poultry trade in the spread of viruses remain enigmatic. In this study, we integrate ecosystem interactions into a phylogeographic model to assess the contribution of wild and domestic hosts to AIV distribution and persistence. Analysis of globally sampled AIV datasets shows frequent two-way transmission between wild and domestic ecosystems. In general, viral flow from domestic to wild bird populations was restricted to within a geographic region. In contrast, spillover from wild to domestic populations occurred both within and between regions. Wild birds mediated long-distance dispersal at intercontinental scales whereas viral spread among poultry populations was a major driver of regional spread. Viral spread between poultry flocks frequently originated from persistent lineages circulating in regions of intensive poultry production. Our analysis of long-term surveillance data demonstrates that meaningful insights can be inferred from integrating ecosystem into phylogeographic reconstructions that may be consequential for pandemic preparedness and livestock protection. ? 2016 Bahl et al.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20191101
dc.subjectArticle
dc.subjectavian influenza virus
dc.subjectdisease surveillance
dc.subjectecosystem health
dc.subjectgene flow
dc.subjectgene sequence
dc.subjectmigration
dc.subjectnonhuman
dc.subjectpandemic
dc.subjectphylogenetic tree
dc.subjectphylogeography
dc.subjectpoultry
dc.subjectpoultry production
dc.subjectsampling
dc.subjectvirus transmission
dc.subjectanimal
dc.subjectbird
dc.subjectecosystem
dc.subjectInfluenza A virus
dc.subjectInfluenza in Birds
dc.subjectpandemic
dc.subjectveterinary
dc.subjectvirology
dc.subjectwild animal
dc.subjectAnimals
dc.subjectAnimals, Wild
dc.subjectBirds
dc.subjectEcosystem
dc.subjectInfluenza A virus
dc.subjectInfluenza in Birds
dc.subjectPandemics
dc.subjectPhylogeography
dc.subjectPoultry
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.ppat.1005620
dc.description.sourcetitlePLoS Pathogens
dc.description.volume12
dc.description.issue5
dc.description.pagee1005620
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