Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.ppat.1005620
Title: Ecosystem Interactions Underlie the Spread of Avian Influenza A Viruses with Pandemic Potential
Authors: Bahl J. 
Pham T.T.
Hill N.J.
Hussein I.T.M.
Ma E.J.
Easterday B.C.
Halpin R.A.
Stockwell T.B.
Wentworth D.E.
Kayali G.
Krauss S.
Schultz-Cherry S.
Webster R.G.
Webby R.J.
Swartz M.D.
Smith G.J.D. 
Runstadler J.A.
Keywords: Article
avian influenza virus
disease surveillance
ecosystem health
gene flow
gene sequence
migration
nonhuman
pandemic
phylogenetic tree
phylogeography
poultry
poultry production
sampling
virus transmission
animal
bird
ecosystem
Influenza A virus
Influenza in Birds
pandemic
veterinary
virology
wild animal
Animals
Animals, Wild
Birds
Ecosystem
Influenza A virus
Influenza in Birds
Pandemics
Phylogeography
Poultry
Issue Date: 2016
Citation: Bahl J., Pham T.T., Hill N.J., Hussein I.T.M., Ma E.J., Easterday B.C., Halpin R.A., Stockwell T.B., Wentworth D.E., Kayali G., Krauss S., Schultz-Cherry S., Webster R.G., Webby R.J., Swartz M.D., Smith G.J.D., Runstadler J.A. (2016). Ecosystem Interactions Underlie the Spread of Avian Influenza A Viruses with Pandemic Potential. PLoS Pathogens 12 (5) : e1005620. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1005620
Abstract: Despite evidence for avian influenza A virus (AIV) transmission between wild and domestic ecosystems, the roles of bird migration and poultry trade in the spread of viruses remain enigmatic. In this study, we integrate ecosystem interactions into a phylogeographic model to assess the contribution of wild and domestic hosts to AIV distribution and persistence. Analysis of globally sampled AIV datasets shows frequent two-way transmission between wild and domestic ecosystems. In general, viral flow from domestic to wild bird populations was restricted to within a geographic region. In contrast, spillover from wild to domestic populations occurred both within and between regions. Wild birds mediated long-distance dispersal at intercontinental scales whereas viral spread among poultry populations was a major driver of regional spread. Viral spread between poultry flocks frequently originated from persistent lineages circulating in regions of intensive poultry production. Our analysis of long-term surveillance data demonstrates that meaningful insights can be inferred from integrating ecosystem into phylogeographic reconstructions that may be consequential for pandemic preparedness and livestock protection. ? 2016 Bahl et al.
Source Title: PLoS Pathogens
URI: https://scholarbank.nus.edu.sg/handle/10635/161915
ISSN: 15537366
DOI: 10.1371/journal.ppat.1005620
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