Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0008452
Title: Influenza in outpatient ILI case-patients in national hospital-based surveillance, Bangladesh, 2007-2008
Authors: Zaman R.U.
Alamgir A.S.M.
Rahman M.
Azziz-Baumgartner E.
Gurley E.S.
Sharker M.A.Y.
Brooks W.A.
Azim T.
Fry A.M.
Lindstrom S.
Gubareva L.V.
Xu X.
Garten R.J.
Hossain M.J.
Khan S.U.
Faruque L.I.
Ameer S.S.
Klimov A.I.
Rahman M. 
Luby S.P.
Keywords: acute respiratory tract disease
adolescent
adult
age distribution
aged
article
Bangladesh
child
disease surveillance
female
flu like syndrome
geographic distribution
human
incidence
infant
influenza
Influenza virus A
Influenza virus B
major clinical study
male
outpatient
seasonal variation
animal
Bangladesh
demography
geographic information system
geography
health care personnel
hospital
influenza
middle aged
outpatient
poultry
reproducibility
reverse transcription polymerase chain reaction
season
sentinel surveillance
statistics
virology
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Animals
Bangladesh
Child
Demography
Female
Geographic Information Systems
Geography
Health Personnel
Hospitals
Humans
Influenza, Human
Male
Middle Aged
Outpatients
Poultry
Reproducibility of Results
Reverse Transcriptase Polymerase Chain Reaction
Seasons
Sentinel Surveillance
Young Adult
Issue Date: 2009
Citation: Zaman R.U., Alamgir A.S.M., Rahman M., Azziz-Baumgartner E., Gurley E.S., Sharker M.A.Y., Brooks W.A., Azim T., Fry A.M., Lindstrom S., Gubareva L.V., Xu X., Garten R.J., Hossain M.J., Khan S.U., Faruque L.I., Ameer S.S., Klimov A.I., Rahman M., Luby S.P. (2009). Influenza in outpatient ILI case-patients in national hospital-based surveillance, Bangladesh, 2007-2008. PLoS ONE 4 (12) : e8452. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0008452
Abstract: Background: Recent population-based estimates in a Dhaka low-income community suggest that influenza was prevalent among children. To explore the epidemiology and seasonality of influenza throughout the country and among all age groups, we established nationally representative hospital-based surveillance necessary to guide influenza prevention and control efforts. Methodolgy/Principal Findings: We conducted influenza-like illness and severe acute respiratory illness sentinel surveillance in 12 hospitals across Bangladesh during May 2007-December 2008. We collected specimens from 3,699 patients, 385 (10%) which were influenza positive by real time RT-PCR. Among the sample-positive patients, 192 (51%) were type A and 188 (49%) were type B. Hemagglutinin subtyping of type A viruses detected 137 (71%) A/H1 and 55 (29%) A/H3, but no A/H5 or other novel influenza strains. The frequency of influenza cases was highest among children aged under 5 years (44%), while the proportions of laboratory confirmed cases was highest among participants aged 11-15 (18%). We applied kriging, a geo-statistical technique, to explore the spatial and temporal spread of influenza and found that, during 2008, influenza was first identified in large port cities and then gradually spread to other parts of the country. We identified a distinct influenza peak during the rainy season (May-September). Conclusions/Significance: Our surveillance data confirms that influenza is prevalent throughout Bangladesh, affecting a wide range of ages and causing considerable morbidity and hospital care. A unimodal influenza seasonality may allow Bangladesh to time annual influenza prevention messages and vaccination campaigns to reduce the national influenza burden. To scale-up such national interventions, we need to quantify the national rates of influenza and the economic burden associated with this disease through further studies.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161825
ISSN: 19326203
DOI: 10.1371/journal.pone.0008452
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