Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0010868
DC Field | Value | |
---|---|---|
dc.title | Mutually positive regulatory feedback loop between interferons and estrogen receptor-? in mice: Implications for sex bias in autoimmunity | |
dc.contributor.author | Panchanathan R. | |
dc.contributor.author | Shen H. | |
dc.contributor.author | Zhang X. | |
dc.contributor.author | Ho S. | |
dc.contributor.author | Choubey D. | |
dc.date.accessioned | 2019-11-07T08:01:35Z | |
dc.date.available | 2019-11-07T08:01:35Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Panchanathan R., Shen H., Zhang X., Ho S., Choubey D. (2010). Mutually positive regulatory feedback loop between interferons and estrogen receptor-? in mice: Implications for sex bias in autoimmunity. PLoS ONE 5 (5) : e10868. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0010868 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161809 | |
dc.description.abstract | Background:Systemic lupus erythematosus (SLE), an autoimmune disease, predominantly affects women of childbearing age. Moreover, increased serum levels of interferon-a (IFN-?) are associated with the disease. Although, the female sex hormone estrogen (E2) is implicated in sex bias in SLE through up-regulation of IFN-? expression, the molecular mechanisms remain unknown. Here we report that activation of IFN (? or ?)-signaling in immune cells up-regulates expression of estrogen receptor-a (ERa; encoded by the Esr1 gene) and stimulates expression of target genes. Methodology/Principal Findings:We found that treatment of mouse splenic cells and mouse cell lines with IFN (? or ?) increased steady-state levels of ER? mRNA and protein. The increase in the ER? mRNA levels was primarily due to the transcriptional mechanisms and it was dependent upon the activation of signal transducer and activator of transcription-1 (STAT1) factor by IFN. Moreover, the IFN-treatment of cells also stimulated transcription of a reporter gene, expression of which was driven by the promoter region of the murine Esr1 gene. Notably, splenic cells from pre-autoimmune lupus-prone (NZB × NZW)F1 female mice had relatively higher steady-state levels of mRNAs encoded by the IFN and ER?-responsive genes as compared to the age-matched males. Conclusions/Significance:Our observations identify a novel mutually positive regulatory feedback loop between IFNs and ERa in immune cells in mice and support the idea that activation of this regulatory loop contributes to sex bias in SLE. © 2010 Panchanathan et al. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | alpha interferon | |
dc.subject | estrogen | |
dc.subject | estrogen receptor alpha | |
dc.subject | gamma interferon | |
dc.subject | messenger RNA | |
dc.subject | STAT1 protein | |
dc.subject | animal cell | |
dc.subject | animal cell culture | |
dc.subject | article | |
dc.subject | autoimmunity | |
dc.subject | cell stimulation | |
dc.subject | controlled study | |
dc.subject | female | |
dc.subject | gender bias | |
dc.subject | gene expression regulation | |
dc.subject | gene function | |
dc.subject | gene targeting | |
dc.subject | genetic association | |
dc.subject | immunoregulation | |
dc.subject | interferon induction | |
dc.subject | intracellular signaling | |
dc.subject | male | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | positive feedback | |
dc.subject | promoter region | |
dc.subject | protein expression | |
dc.subject | receptor upregulation | |
dc.subject | spleen cell | |
dc.subject | steady state | |
dc.subject | systemic lupus erythematosus | |
dc.subject | transcription initiation | |
dc.subject | transcription regulation | |
dc.subject | wild type | |
dc.subject | Animals | |
dc.subject | Autoimmunity | |
dc.subject | Cell Line, Tumor | |
dc.subject | Estradiol | |
dc.subject | Estrogen Receptor alpha | |
dc.subject | Feedback, Physiological | |
dc.subject | Female | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Interferons | |
dc.subject | Male | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | RNA, Messenger | |
dc.subject | Sex Characteristics | |
dc.subject | Signal Transduction | |
dc.subject | STAT1 Transcription Factor | |
dc.subject | Transcription, Genetic | |
dc.subject | Murinae | |
dc.subject | Mus | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.description.doi | 10.1371/journal.pone.0010868 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 5 | |
dc.description.issue | 5 | |
dc.description.page | e10868 | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1371_journal_pone_0010868.pdf | 604.56 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License