Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0109854
Title: Laminin ?4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain
Authors: Vaicik M.K.
Kortesmaa J.T.
Movérare-Skrtic S.
Kortesmaa J.
Soininen R.
Bergström G.
Ohlsson C.
Chong L.Y. 
Rozell B.
Emont M.
Cohen R.N.
Brey E.M.
Tryggvason K. 
Keywords: laminin alpha4
Lama4 protein, mouse
laminin
adipose tissue
age
animal cell
animal tissue
Article
bioaccumulation
controlled study
epididymis fat
extracellular matrix
fat mass
knockout mouse
laminin alpha4 gene
lipid composition
lipid diet
lipogenesis
male
mouse
nonhuman
obesity
protein function
tissue expansion
tissue structure
weight gain
wild type
adipocyte
adipose tissue
aging
animal
C57BL mouse
cell size
deficiency
feeding behavior
metabolism
pathology
subcutaneous fat
white adipose tissue
Mus
Adipocytes
Adipose Tissue
Adipose Tissue, White
Aging
Animals
Cell Size
Diet, High-Fat
Feeding Behavior
Laminin
Lipogenesis
Male
Mice, Inbred C57BL
Obesity
Subcutaneous Fat
Weight Gain
Issue Date: 2014
Citation: Vaicik M.K., Kortesmaa J.T., Movérare-Skrtic S., Kortesmaa J., Soininen R., Bergström G., Ohlsson C., Chong L.Y., Rozell B., Emont M., Cohen R.N., Brey E.M., Tryggvason K. (2014). Laminin ?4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS ONE 9 (10) : e109854. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0109854
Rights: Attribution 4.0 International
Abstract: Obesity is a global epidemic that contributes to the increasing medical burdens related to type 2 diabetes, cardiovascular disease and cancer. A better understanding of the mechanisms regulating adipose tissue expansion could lead to therapeutics that eliminate or reduce obesity-associated morbidity and mortality. The extracellular matrix (ECM) has been shown to regulate the development and function of numerous tissues and organs. However, there is little understanding of its function in adipose tissue. In this manuscript we describe the role of laminin α4, a specialized ECM protein surrounding adipocytes, on weight gain and adipose tissue function. Adipose tissue accumulation, lipogenesis, and structure were examined in mice with a null mutation of the laminin α4 gene (Lama4−/−) and compared to wild-type (Lama4+/+) control animals. Lama4−/− mice exhibited reduced weight gain in response to both age and high fat diet. Interestingly, the mice had decreased adipose tissue mass and altered lipogenesis in a depot-specific manner. In particular, epididymal adipose tissue mass was specifically decreased in knock-out mice, and there was also a defect in lipogenesis in this depot as well. In contrast, no such differences were observed in subcutaneous adipose tissue at 14 weeks. The results suggest that laminin α4 influences adipose tissue structure and function in a depot-specific manner. Alterations in laminin composition offers insight into the roll the ECM potentially plays in modulating cellular behavior in adipose tissue expansion. © 2014 Vaicik et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161768
ISSN: 19326203
DOI: 10.1371/journal.pone.0109854
Rights: Attribution 4.0 International
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