Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0117044
Title: Association between family history risk categories and prevalence of diabetes in chinese population
Authors: Zhang J.
Yang Z.
Xiao J.
Xing X.
Lu J.
Weng J.
Jia W.
Ji L.
Shan Z.
Liu J. 
Tian H.
Ji Q.
Zhu D.
Ge J.
Chen L.
Guo X.
Zhao Z.
Li Q.
Zhou Z.
Lin L.
Wang N.
Yang W.
Keywords: cholesterol
glucose
insulin
low density lipoprotein cholesterol
triacylglycerol
insulin
adult
age distribution
Article
assessment of humans
body mass
Chinese
classification
comparative study
controlled study
cross-sectional study
diabetes mellitus
disease association
family history
female
first degree relative
glucose blood level
high risk population
homeostatic model assessment estimated insulin resistance
human
insulin blood level
insulin release
insulin resistance
insulinogenic index
low risk population
major clinical study
male
Matsuda insulin sensitivity index
middle aged
obesity
onset age
oral glucose tolerance test
prevalence
retrospective study
risk assessment
risk factor
trend study
young adult
China
diabetes mellitus
glucose intolerance
metabolism
physiology
population
prevalence
secretion (process)
Adult
China
Diabetes Mellitus
Female
Glucose Intolerance
Humans
Insulin
Insulin Resistance
Male
Middle Aged
Population
Prevalence
Risk Factors
Young Adult
Issue Date: 2015
Citation: Zhang J., Yang Z., Xiao J., Xing X., Lu J., Weng J., Jia W., Ji L., Shan Z., Liu J., Tian H., Ji Q., Zhu D., Ge J., Chen L., Guo X., Zhao Z., Li Q., Zhou Z., Lin L., Wang N., Yang W. (2015). Association between family history risk categories and prevalence of diabetes in chinese population. PLoS ONE 10 (2) : e0117044. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0117044
Rights: Attribution 4.0 International
Abstract: Aim To investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population. Methods The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals (age ?20 years) in the 2007-2008 China National Diabetes and Metabolism Disorders Study. The family history risk categories of diabetes were high, moderate, and average (FH2 and FH1: at least two generations and one generation of first-degree relatives with diabetes, respectively; FH0: no first-degree relatives with diabetes). Results The age- and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4-39.7%) in FH2, 20.1% (95% CI: 18.2- 22.1%) in FH1, and 8.4% (95% CI: 7.9-8.9%) in FH0 (P < 0.0001). The calculated homeostatic model assessment-estimated insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), and insulinogenic index (?I30/ ÄG30) values showed significant trending changes among the three risk categories, with the most negative effects in FH2. Multivariate logistic regression analysis showed that the odds ratios of having diabetes were 6.16 (95% CI: 4.46- 8.50) and 2.86 (95% CI: 2.41-3.39) times higher in FH2 and FH1, respectively, than in FH0 after adjustment for classical risk factors for diabetes. Conclusions Family history risk categories of diabetes have a significant, independent, and graded association with the prevalence of this disease in the Chinese population.. © 2015 Zhang et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161746
ISSN: 19326203
DOI: 10.1371/journal.pone.0117044
Rights: Attribution 4.0 International
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