Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pbio.1001199
Title: | Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer | Authors: | Maxwell C.A. Benítez J. Gómez-Baldó L. Osorio A. Bonifaci N. Fernández-Ramires R. Costes S.V. Guinó E. Chen H. Evans G.J.R. Mohan P. Català I. Petit A. Aguilar H. Villanueva A. Aytes A. Serra-Musach J. Rennert G. Lejbkowicz F. Peterlongo P. Manoukian S. Peissel B. Ripamonti C.B. Bonanni B. Viel A. Allavena A. Bernard L. Radice P. Friedman E. Kaufman B. Laitman Y. Dubrovsky M. Milgrom R. Jakubowska A. Cybulski C. Gorski B. Jaworska K. Durda K. Sukiennicki G. Lubi?ski J. Shugart Y.Y. Domchek S.M. Letrero R. Weber B.L. Hogervorst F.B.L. Rookus M.A. Collee J.M. Devilee P. Ligtenberg M.J. van der Luijt R.B. Aalfs C.M. Waisfisz Q. Wijnen J. van Roozendaal C.E.P. HEBON Hereditary Breast and Ovarian Cancer Group EMBRACE Centre for Cancer Genetic Epidemiology Easton D.F. Peock S. Cook M. Oliver C. Frost D. Harrington P. Lalloo F. Eeles R. Izatt L. Chu C. Eccles D. Douglas F. Brewer C. Nevanlinna H. Heikkinen T. Couch F.J. Wang X. Lindor N.M. Godwin A.K. Caligo M.A. Lombardi G. Loman N. Karlsson P. Ehrencrona H. von Wachenfeldt A. SWE-BRCA Swedish Breast Cancer Study Barkardottir R. Hamann U. Rashid M.U. Lasa A. Caldés T. Andrés R. Schmitt M. Assmann V. Stevens K. Offit K. Curado J. Tilgner H. Guigó R. Aiza G. Brunet J. Martrat G. Urruticoechea A. Blanco I. Tihomirova L. Goldgar D.E. Buys S. John E.M. Miron A. Southey M. Daly M.B. BCFR Breast Cancer Family Registry Schmutzler R.K. Wappenschmidt B. Meindl A. Arnold N. Deissler H. Varon-Mateeva R. Sutter C. Niederacher D. Imyamitov E. Sinilnikova O.M. Sinilnikova O.M. Stoppa-Lyonne D. Mazoyer S. Verny-Pierre C. Castera L. de Pauw A. Bignon Y.-J. Uhrhammer N. Peyrat J.-P. Vennin P. Ferrer S. Collonge-Rame M.-A. Mortemousque I. GEMO Study Collaborators GEMO Study Spurdle A.B. Beesley J. Chen X. Healey S. Barcellos-Hoff M.H. Barcellos-Hoff M.H. Gruber S.B. Lázaro C. Capellá G. McGuffog L. Nathanson K.L. Chenevix-Trench G. Fleisch M.C. Moreno V. Pujana M.A. |
Keywords: | BRCA1 protein BRCA2 protein cell protein estrogen receptor nuclear protein protein AURKA protein RHAMM protein TPX2 unclassified drug aurora kinase BRCA1 protein BRCA1 protein, human BRCA2 protein BRCA2 protein, human estrogen receptor Hermes antigen hyaluronan mediated motility receptor hyaluronan-mediated motility receptor protein serine threonine kinase scleroprotein article breast cancer breast carcinogenesis cancer risk cell polarity controlled study epithelial apicobasal polarization gene locus gene mutation genetic analysis genetic variability human human cell microtubule molecular interaction negative feedback penetrance protein analysis protein function breast breast tumor cytology epithelium cell female genetic predisposition genetics genotype HeLa cell heterozygote metabolism pathology physiology tumor cell line tumor suppressor gene ultrastructure Antigens, CD44 BRCA1 Protein BRCA2 Protein Breast Breast Neoplasms Cell Line, Tumor Cell Polarity Epithelial Cells Extracellular Matrix Proteins Female Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Genetic Variation Genotype HeLa Cells Heterozygote Humans Microtubules Protein-Serine-Threonine Kinases Receptors, Estrogen |
Issue Date: | 2011 | Citation: | Maxwell C.A., Benítez J., Gómez-Baldó L., Osorio A., Bonifaci N., Fernández-Ramires R., Costes S.V., Guinó E., Chen H., Evans G.J.R., Mohan P., Català I., Petit A., Aguilar H., Villanueva A., Aytes A., Serra-Musach J., Rennert G., Lejbkowicz F., Peterlongo P., Manoukian S., Peissel B., Ripamonti C.B., Bonanni B., Viel A., Allavena A., Bernard L., Radice P., Friedman E., Kaufman B., Laitman Y., Dubrovsky M., Milgrom R., Jakubowska A., Cybulski C., Gorski B., Jaworska K., Durda K., Sukiennicki G., Lubi?ski J., Shugart Y.Y., Domchek S.M., Letrero R., Weber B.L., Hogervorst F.B.L., Rookus M.A., Collee J.M., Devilee P., Ligtenberg M.J., van der Luijt R.B., Aalfs C.M., Waisfisz Q., Wijnen J., van Roozendaal C.E.P., HEBON Hereditary Breast and Ovarian Cancer Group, EMBRACE Centre for Cancer Genetic Epidemiology, Easton D.F., Peock S., Cook M., Oliver C., Frost D., Harrington P., Lalloo F., Eeles R., Izatt L., Chu C., Eccles D., Douglas F., Brewer C., Nevanlinna H., Heikkinen T., Couch F.J., Wang X., Lindor N.M., Godwin A.K., Caligo M.A., Lombardi G., Loman N., Karlsson P., Ehrencrona H., von Wachenfeldt A., SWE-BRCA Swedish Breast Cancer Study, Barkardottir R., Hamann U., Rashid M.U., Lasa A., Caldés T., Andrés R., Schmitt M., Assmann V., Stevens K., Offit K., Curado J., Tilgner H., Guigó R., Aiza G., Brunet J., Martrat G., Urruticoechea A., Blanco I., Tihomirova L., Goldgar D.E., Buys S., John E.M., Miron A., Southey M., Daly M.B., BCFR Breast Cancer Family Registry, Schmutzler R.K., Wappenschmidt B., Meindl A., Arnold N., Deissler H., Varon-Mateeva R., Sutter C., Niederacher D., Imyamitov E., Sinilnikova O.M., Sinilnikova O.M., Stoppa-Lyonne D., Mazoyer S., Verny-Pierre C., Castera L., de Pauw A., Bignon Y.-J., Uhrhammer N., Peyrat J.-P., Vennin P., Ferrer S., Collonge-Rame M.-A., Mortemousque I., GEMO Study Collaborators GEMO Study, Spurdle A.B., Beesley J., Chen X., Healey S., Barcellos-Hoff M.H., Barcellos-Hoff M.H., Gruber S.B., Lázaro C., Capellá G., McGuffog L., Nathanson K.L., Chenevix-Trench G., Fleisch M.C., Moreno V., Pujana M.A. (2011). Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biology 9 (11) : e1001199. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pbio.1001199 | Rights: | Attribution 4.0 International | Abstract: | Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ( |
Source Title: | PLoS Biology | URI: | https://scholarbank.nus.edu.sg/handle/10635/161649 | ISSN: | 15449173 | DOI: | 10.1371/journal.pbio.1001199 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1371_journal_pbio_1001199.pdf | 928.54 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License